Publications by authors named "Daredzhan Kapanadze"
Cerebral vein thrombosis is a rare, life-threatening condition that has now become more commonly diagnosed due to advancements in imaging techniques. Our purpose is to improve understanding of pathogenesis, diagnosis and pregnancy and IVF management in patients with a history of cerebral thrombosis. We present an overview of the modern tactics of anticoagulant therapy for cerebral thrombosis with a focus on pregnancy, the use of hormone therapy, and assisted reproductive technologies.
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- Recent developments have improved our understanding of the molecular processes that lead to thrombus formation, particularly regarding deep vein thrombosis (DVT), which can be triggered by various factors like trauma, immobility, or genetic issues.
- About half of DVT cases are unprovoked, involving mechanisms such as venous stasis and hypoxia, raising the importance of immunothrombosis, especially during conditions like COVID-19 that exacerbate inflammation and promote microthrombi formation.
- Research involving animal models and clinical studies has revealed the intricate relationship between immune cells, blood components, and various factors influencing coagulation, providing a deeper insight into the causes of hypercoagulability and venous thromboembolism.
Article Synopsis
- - Thrombotic microangiopathy (TMA) is a group of disorders where small blood vessel clotting causes organ damage, including conditions like thrombotic thrombocytopenic purpura (TTP) and hemolytic-uremic syndrome (HUS), each with unique causes and impacts on health.
- - In TMA, inflammation leads to endothelial damage and activates platelet and coagulation processes, often linked to low ADAMTS13 enzyme levels, particularly in cancer patients undergoing chemotherapy, which raises thrombotic risk by increasing the VWF/ADAMTS13 ratio.
- - Treatment focuses on diagnosing the specific cause and may include therapies to inhibit complement activation, supportive care, and plasmapheresis
Pediatric antiphospholipid syndrome: is it the same as an adult?
J Matern Fetal Neonatal Med
December 2024
Importance: Antiphospholipid syndrome in neonates and children is a rare, but in some cases life-threatening condition with arterial and/or venous thrombosis and/or non-thrombotic neurological, skin, ophthalmological and other manifestations.
Observations: This review highlights the available information about the features of pediatric APS, including the rare catastrophic form, the differences between pediatric and adult APS, and the role of genetic thrombophilia in APS manifestation.
Conclusions And Relevance: The clinical manifestations and treatment options for APS in children may differ from those in adults, and prescribing therapy can be challenging due to the unique clinical and morphological characteristics of the pediatric patient.