Publications by authors named "Dardick J"
Article Synopsis
- Timely placement of external ventricular drains (EVDs) is crucial in emergency neurosurgery, and the introduction of portable electrical drills like the Hubly drill offers potential improvements in the procedure.
- In a study, two patients successfully received EVDs using the new portable drill, with quick access times and no complications observed during the procedures.
- The findings suggest that the smart autostop feature of the drill could enhance safety and efficiency in EVD placement, highlighting the need for further development and research in this technology.
Objective: The Glasgow Coma Scale-Pupils (GCS-P) score has been suggested to better predict patient outcomes compared with GCS alone, while avoiding the need for more complex clinical models. This study aimed to compare the prognostic ability of GCS-P versus GCS in a national cohort of traumatic subdural hematoma (SDH) patients.
Methods: Patient data were obtained from the National Trauma Data Bank (2017-2019).
Objective: Careful hematologic management is required in surgical patients with traumatic acute subdural hematoma (aSDH) taking antithrombotic medications. We sought to compare outcomes between patients with aSDH taking antithrombotic medications at admission who received antithrombotic reversal with patients with aSDH not taking antithrombotics.
Methods: Retrospective review identified patients with traumatic aSDH requiring surgical evacuation.
Article Synopsis
- Acute subdural hematoma (aSDH) after traumatic brain injury often requires urgent surgical procedures, specifically craniotomy (CO) or decompressive craniectomy (DC), and the study aimed to compare outcomes and identify variables linked to each approach.
- The study analyzed data from multiple centers, identifying significant differences in patient characteristics between those undergoing CO and DC, including age, gender, and severity of symptoms at presentation.
- Findings indicated that patients undergoing DC were generally younger and more likely to have poorer clinical outcomes, with DC being associated with higher mortality rates both during hospitalization and at 90 days and 1 year post-surgery after adjusting for patient differences.
Background: Blunt cerebrovascular injury (BCVI), defined as blunt traumatic injury to the carotid or vertebral arteries, is associated with significant risk of stroke and mortality. Cervical spine trauma is a recognized risk factor for BCVI.
Objective: The objective of this study was to identify significant predictors of BCVI and its sequelae in patients with known cervical spine injury.
Flow diversion is an evolving endovascular modality for treating intracranial aneurysms. Although rare, serious adverse events following flow diversion may include ischemic stroke, intracranial hemorrhage, or delayed rupture of the treated aneurysm. This dataset describes 141 flow diversion procedures performed with the Pipeline Embolization Device, Pipeline Flex, or Surpass Streamline on 126 subjects with intracranial aneurysms [1].
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- - Endovascular therapy (EVT) is a standard treatment for acute ischemic stroke (AIS) caused by large vessel occlusion (LVO), but it can lead to a serious complication known as hemorrhagic conversion (HC), and the risk factors for this issue are not well understood.
- - Researchers conducted a retrospective study on 326 adults treated with EVT for AIS over four years to identify the predictors of radiographic and symptomatic HC, finding that factors like a prior ischemic stroke, low Alberta Stroke Program Early CT Score (ASPECTS), and successful recanalization were significant risk factors for HC.
- - For symptomatic hemorrhagic conversion specifically, an elevated international normalized ratio (INR) was identified as a
Objective: To compare safety and efficacy profiles in aneurysms treated with Pipeline Embolization Device or Pipeline Flex versus Surpass Streamline flow diverters (FDs).
Methods: Patients who underwent flow diversion for aneurysm treatment at 2 centers were included. Covariates comprised patient demographics, comorbidities, and aneurysm characteristics.
Article Synopsis
- The study investigates the impact of transfer status on clinical outcomes in patients undergoing mechanical thrombectomy for large vessel occlusions in ischemic stroke treatment.
- A comparison was made between patients directly admitted to a comprehensive stroke center and those transferred from primary stroke centers, with no significant differences found in 90-day outcomes between the two groups.
- Despite the concerns about delays in treatment caused by the Hub and Spoke model, transfer status did not independently predict clinical outcomes, suggesting that this model may not adversely affect patient recovery in this context.
Introduction: Endovascular thrombectomy (EVT) is a well-established treatment of acute ischemic stroke. Variability in outcomes among thrombectomy patients results in a need for patient centered approaches to recovery. Identifying key factors that are associated with outcomes can help prognosticate and direct resources for continued improvement post-treatment.
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- - Despite regular vaccinations, influenza still causes serious health problems and deaths worldwide, indicating the need for a more effective vaccine that stimulates immune responses like antibody-dependent cellular cytotoxicity (ADCC).
- - Researchers developed a protective vaccine, ΔgD-2, against herpes simplex virus (HSV) that also produces a strong antibody response; they then integrated the hemagglutinin (HA) gene from an H1N1 strain into this vaccine to target influenza.
- - The new ΔgD-2::HA vaccine was shown to effectively protect mice from influenza, even with prior HSV exposure, while also maintaining protection against HSV infections and working in mice lacking certain immune receptors.
Background: Altered mental status (AMS) is a common neurological manifestation of COVID-19 infection in hospitalized patients. The principal causes of AMS have yet to be determined. We aimed to identify the common causes of AMS in patients with COVID-19 presenting to the emergency department with AMS on arrival.
View Article and Find Full Text PDFObjective: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is protean in its manifestations, affecting nearly every organ system. However, nervous system involvement and its effect on disease outcome are poorly characterized. The objective of this study was to determine whether neurologic syndromes are associated with increased risk of inpatient mortality.
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- More young people are having strokes, and most of these strokes are called cryptogenic, which means doctors aren’t sure what caused them.
- Researchers studied patients aged 18-49 to find out if certain heart health issues were more common in those with different types of strokes.
- They found that many young people with cryptogenic strokes had issues like high blood pressure and diabetes, while others had heart problems like heart failure and abnormal heart sizes.
Objective: To test the hypothesis that the prevalence of cervical artery dissection remains constant across age groups, we evaluated the relationship between age and cervical artery dissection in patients with stroke using a nationally representative sample from the United States.
Methods: We used inpatient claims data included in the 2012-2015 releases of the National Inpatient Sample (NIS). We used validated ICD-9-CM codes to identify adults hospitalized with ischemic stroke and a concomitant diagnosis of carotid or vertebral artery dissection.
The Impact of COVID-19 on Emergent Large-Vessel Occlusion: Delayed Presentation Confirmed by ASPECTS.
AJNR Am J Neuroradiol
December 2020
Background And Purpose: Our hypothesis is that the COVID-19 pandemic led to delayed presentations for patients with acute ischemic stroke. This study evaluates the impact of the coronavirus disease 2019 pandemic on presentation, treatment, and outcomes of patients with emergent large-vessel occlusion using data from a large health system in the Bronx, New York.
Materials And Methods: We performed a retrospective cohort study of 2 cohorts of consecutive patients with emergent large-vessel occlusion admitted to 3 Montefiore Health System hospitals in the Bronx from January 1 to February 17, 2020, (prepandemic) and March 1 to April 17, 2020 (pandemic).
Background: This study evaluates the mortality risk of patients with emergent large vessel occlusion (ELVO) and COVID-19 during the pandemic.
Methods: We performed a retrospective cohort study of two cohorts of consecutive patients with ELVO admitted to a quaternary hospital from March 1 to April 17, 2020. We abstracted data from electronic health records on baseline, biomarker profiles, key time points, quality measures and radiographic data.
Background: Realistic virtual reality (VR) simulators have greatly expanded the tools available for training surgeons and interventionalists. While this technology is effective in improving performance in many fields, it has never been evaluated for neuroendovascular procedures. This study aims to determine whether VR is an effective tool for improving neuroendovascular skill among trainees.
View Article and Find Full Text PDFCytokinesis requires the cooperation of many cytoskeletal and membrane regulators. Most of the major players required for cytokinesis are known, but the temporal regulation and adaptations for different cell types are less understood. KIF20B (previously called MPHOSPH1 or MPP1) is a member of the Kinesin-6 family, which also includes the better-known members KIF23/MKLP1 and KIF20A/MKLP2.
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