Publications by authors named "Darcy Garza Miyazato"
Article Synopsis
- Ginsenoside Rh2 (Rh2) is a ginseng-derived compound known for its varied biological effects and was studied for its interaction with membrane lipids in different phases.
- Rh2 is located deeper within the lipid bilayer in the liquid-disordered phase and reduces lipid acyl chain order, suggesting it may enhance membrane permeability.
- Unlike other saponins like digitonin, Rh2's structure with dihydroxy and glucose groups allows for a unique interaction with membranes without causing significant disruption.
Saponin is the main bioactive component of the Dioscorea species, which are traditionally used for treating chronic diseases. An understanding of the interaction process of bioactive saponins with biomembranes provides insights into their development as therapeutic agents. The biological effects of saponins have been thought to be associated with membrane cholesterol (Chol).
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