Cytoplasmic ezrin and moesin correlate with poor survival in head and neck squamous cell carcinoma.

Members of the 4.1 superfamily of proteins, including ezrin, moesin, merlin, and willin regulate many normal physiologic processes such as cellular shape, motility, and proliferation. In addition, they contribute both to tumor development and tumor progression.

Validation of the histologic risk model in a new cohort of patients with head and neck squamous cell carcinoma.

Background: Half of the patients with head and neck squamous cell carcinoma (HNSCC) can be expected to fail therapy, indicating that more aggressive treatment is warranted for this group. We have developed a novel risk model that can become a basis for developing new treatment paradigms. Here we report on the performance of our model in a new multicenter cohort.

The importance of testing whole stool for Shiga toxin: a clinical and microbiological perspective.

This case report emphasizes the importance of testing whole stool for the presence of Shiga toxin; especially in light of clinical suspicion, or whenever a grossly bloody stool specimen is received in the lab. Since organisms other than Escherichia coli O157:H7 can elaborate Shiga toxin, a negative stool culture for the usual enteric pathogens does not rule out the possibility of a Shiga toxin-mediated pathology in the appropriate clinical setting. The presence of this toxin in stool influences a physician's approach towards the patient's antimicrobial management.