Advancing Non-Invasive Diagnosis of Oral Epithelial Dysplasia: Comparative Insights from In Vivo Optical Coherence Tomography and Histopathology.

Oral epithelial dysplasia (OED) is considered one of the premalignant lesions for oral squamous cell carcinoma (OSCC), for which the five-year disease-free survival rate may vary widely. There has emerged in recent years, therefore, a significant niche for optical coherence tomography (OCT) to non-invasively examine tissue morphology. The present study was conducted to evaluate the diagnostic performance of OCT in distinguishing between mild, moderate, and severe dysplasias and carcinoma in situ (CIS) with histopathological correlations.

In Vivo Optical Coherence Tomography for the Detection, Subtyping, and Margin Assessment of Facial Basal Cell Carcinoma: A Comparative Study with Histopathology.

Basal cell carcinoma (BCC) is the most common skin cancer, with several subtypes that vary from one another in biological behaviour and therapeutic consequences. The aim of the study was to evaluate in vivo OCT diagnostic accuracy to detect and subtype facial BCCs, using histopathology as the gold standard. This single-centre, prospective, diagnostic accuracy study was carried out on 136 patients who were presenting with a total of 220 clinically suspicious facial lesions for BCC.

In vivo optical coherence tomography-guided photodynamic therapy for skin pre-cancer and cancer.

Background: The primary aim of this prospective study is to demonstrate the technical feasibility of OCT to map real tumor margins and to monitor skin changes that occurred post- PDT. Moreover, to optimize PDT efficacy based on the relationship between measured OCT features and treatment outcome.

Material And Methods: A series of 12 patients with overall 18 facial skin lesions were investigated by OCT before surface illumination by PDT to determine tumor free margins.

In vivo optical coherence tomography in assessment of suspicious facial lesions: A prospective study.

Background: Skin cancer continues to be the most common cancer in the Caucasian population. Over the past two decades, researchers around the world started assessing the possibility of diagnosing tissue pathologies by using optical systems. In this study, we aimed to use in vivo optical coherence tomography (OCT) technology to describe the morphologic features of normal and pathologic skin conditions.