CL429 enhances the renewal of intestinal stem cells by upregulating TLR2-YAP1.

Intestinal stem cells (ISCs) play a crucial role in maintaining the equilibrium and regenerative potential of intestinal tissue, thereby ensuring tissue homeostasis and promoting effective tissue regeneration following injury. It has been proven that targeting Toll-like receptors (TLRs) can help prevent radiation-induced damage to the intestine. In this study, we established an intestinal injury model using IR and evaluated the effects of CL429 on ISC regeneration both in vivo and in vitro.

FG-4592 protected haematopoietic system from ionising radiation in mice.

Ionising radiation exposure can lead to acute haematopoietic radiation syndrome. Despite significant advancements in the field of radioprotection, no drugs with high efficacy and low toxicity have yet been approved by the Food and Drug Administration. FG-4592, as a proline hydroxylase inhibitor, may play an important role in radioprotection of the haematopoietic system.

Scleroglucan protects the intestine from irradiation-induced injury by targeting the IL-17 signaling pathway.

Background: Intestinal tissue is extremely sensitive to ionizing radiation (IR), which is easy to cause intestinal radiation sickness, and the mortality rate is very high after exposure. Recent studies have found that intestinal immune cells and intestinal stem cells (ISCs) may play a key role in IR-induced intestinal injury.

Methods: C57BL6 mice matched for age, sex and weight were randomly grouped and intraperitoneal injected with PBS, Scleroglucan (125.

[Community diversity of butterfly in Houhe National Nature Reserve].

In 2003-2004, a field investigation was made on the composition of butterfly community in the Houhe National Nature Reserve of Hubei Province, and the diversity, evenness and dominance of the community on the levels of family, genus and species in spring, summer and autumn were studied by the method of alpha-diversity. The results showed that the species richness, diversity, and dominance indices were the highest in summer, while the evenness index wasthe highest in spring. Nymphalidae was the highest in richness at the level of families, with the value of 32.