Synopsis of recent research by authors named "Daphne Guinn"
- Daphne Guinn's research focuses on understanding the pharmacokinetics and safety of medications used during lactation and pregnancy, addressing significant gaps in knowledge due to the historical exclusion of these populations from clinical trials.
- She has developed physiologically based pharmacokinetic models to assess infant drug exposure through human milk, specifically utilizing compounds like pregabalin and sotalol to inform risk assessments for breastfeeding individuals.
- Guinn's work also includes a critical analysis of pediatric study plans for new oncology drugs, exploring the implications of FDA requirements on drug evaluation and the need for improved data to ensure drug safety in vulnerable populations, including children and pregnant individuals.
