Publications by authors named "Daphne E Boer"
Article Synopsis
- Deficiency in the enzyme glucocerebrosidase (GBA) leads to Gaucher disease, which affects cholesterol metabolism and the breakdown of certain lipids.
- Research shows that recombinant human GBA can also cleave β-xylosides and transxylosylate cholesterol, producing a new compound, di-xylosyl-cholesterol (XylChol), which is reduced in patients with Gaucher disease.
- The study identifies xylosylated ceramide (XylCer) as a potential donor for the formation of XylChol, suggesting that food-derived β-D-xylosides and XylCer might play a role in lipid metabolism in cells.
