Effect of Different Postures on Intraocular Pressure in Open-Angle Glaucoma.

Introduction: This study aims to investigate the pattern of intraocular pressure (IOP) changes in different postures among patients with open-angle glaucoma (OAG).

Methods: A observational study was conducted on a total of 74 patients with OAG (148 eyes). IOP measurements were taken in a variety of positions, including supine, left lateral decubitus, right lateral decubitus, head tilted downwards position with immediate head-up (transient head tilted downwards), seated, seated with head tilted downwards, standing, and walking.

Factors associated with blindness three months following treatment for acute primary angle glaucoma.

Aims: To study the risk factors associated with blindness after treatment of acute primary angle closure (APAC), and to identify the critical time window to decrease rate of blindness.

Methods: In this multicentre retrospective case series, 1030 consecutive subjects (1164 eyes) with APAC in China were recruited. The rates of blindness were analysed up to 3 months after treatment of APAC.

Efficacy of goniosynechialysis for advanced chronic angle-closure glaucoma.

Purpose: To evaluate the intraocular pressure (IOP)-lowering efficacy of goniosynechialysis (GSL) for advanced chronic angle-closure glaucoma (CACG) using a simplified slit-lamp technique.

Patients And Methods: Patients with CACG with one severely affected eye with best-corrected visual acuity below 20/200 and a mildly or functionally unaffected fellow eye were enrolled in this study. All patients underwent ophthalmologic examinations including measurement of visual acuity, best-corrected visual acuity, and IOP; biomicroscopy; specular microscopy; fundus examination; and gonioscopy followed by anterior chamber paracentesis and GSL for nasal peripheral anterior synechiae in the eye with severe CACG.

[Alteration of anterior chamber and angle structure in eyes with primary angle closure after laser peripheral iridotomy].

Objective: To quantitatively evaluate the long-term changes in anterior segment morphology by using ultrasound biomicroscopy (UBM) after laser peripheral iridotomy (LPI) in eyes with primary angle closure (PAC).

Methods: This was a clinical case series study. A total of 54 eyes with PAC of 31 consecutive patients were enrolled.

Correlation between pupil diameter and angle configuration in the dark room provocative test.

Purpose: To study the associations between changes in pupil diameter and in the anterior chamber angle configuration during the dark room provocative test.

Methods: The study included 70 suspects of primary angle closure (study group) and 40 normal participants (control group). Using anterior-segment optical coherence tomography (AS-OCT), we measured the anterior chamber angle configuration and pupil diameter at 3 minutes and at 1.

[Significance of optic disc topography and retinal nerve fiber layer thickness measurement by spectral-domain OCT in diagnosis of glaucoma].

Objective: To study the significance of optic disc tomography and retinal nerve fiber layer (RNFL) thickness measurement by spectral-domain optical coherence tomography (OCT) in the diagnosis of glaucoma.

Methods: It was a noninterventional, observational study. The optic disc topographic parameters and total and regional RNFL thickness were measured by RTVue OCT in 60 normal eyes and 97 glaucomatous eyes.

Comparative study of retinal nerve fibre layer measurement by RTVue OCT and GDx VCC.

Aim: To evaluate the diagnostic performances and correlations of retinal nerve fibre layer (RNFL) thickness measured by RTVue OCT and GDx variable corneal compensation (VCC).

Methods: The total and regional RNFL thickness were measured by RTVue OCT and GDx VCC in 62 normal eyes and 72 glaucomatous eyes of Chinese subjects. The RNFL thickness profiles of normal and glaucomatous eyes by RTVue OCT are plotted.

Prospective evaluation of changes in anterior segment morphology after laser iridotomy in Chinese eyes by rotating Scheimpflug camera imaging.

Background: To investigate the 3-D morphology changes of anterior segment in primary angle-closure suspect and primary angle-closure after laser peripheral iridotomy (LPI) using rotating Scheimpflug camera.

Methods: A total of 37 eyes of 25 patients were enrolled in the study. Just before and after LPI, rotating Scheimpflug camera was performed on each selected eye by one skilled ophthalmologist.

Measurement of anterior chamber volume with rotating scheimpflug camera and anterior segment optical coherence tomography.

Background: Measurement of anterior segment parameters plays an important role in diagnosis and treatment of glaucoma. The objective of this study was to evaluate the repeatability and reproducibility of anterior chamber volume (ACV) measurements with rotating scheimpflug camera (RSC) and to examine agreement with anterior segment optical coherence tomography (AS-OCT).

Methods: Thirty nine healthy normal subjects were recruited from the Eye Center of Tongren Hospital.

Accuracy and repeatability of direct ciliary sulcus diameter measurements by full-scale 50-megahertz ultrasound biomicroscopy.

Background: Phakic intraocular lens (pIOL) implantation has been a popular means for the treatment of high ametropia. Measurements of ciliary sulcus diameter is important for pIOL size determining. But till now, no perfect system can directly measure it.

Inhibitory effect of activin A on activation of lipopolysaccharide-stimulated mouse macrophage RAW264.7 cells.

Activin A is a member of transforming growth factor beta (TGF-beta) superfamily, which is also named restrictin-P, and can inhibit the secretion of nitric oxide (NO) and interleukin-1beta (IL-1beta) from LPS-activated mouse macrophages. In this study, the regulation effect and possible mechanism of activin A as an anti-inflammatory factor on lipopolysaccharide (LPS)-activated macrophages were investigated in vitro. It was observed that activin A could not only decrease the secretion of IL-1beta and NO, as well as the mRNA expressions of IL-1beta and iNOS, but also suppress the pinocytosis of mouse macrophage cell line RAW264.