Case report: The effective response to pembrolizumab in combination with bevacizumab in the treatment of a recurrent glioblastoma with multiple extracranial metastases.

Multiple extracranial metastases of recurrent glioblastoma are rare and often indicate a very poor prognosis. The main conventional treatments are chemotherapy, radiotherapy, chemoradiotherapy or antiangiogenic therapy. Median overall survival is 2.

Rapid subcutaneous progression after immunotherapy in pretreated patients with metastatic carcinoma: two case reports.

There is heterogeneity in cancer patients' responses to immune checkpoint inhibitors (ICIs), including hyperprogression, which is very rapid tumor progression following immunotherapy, and pseudoprogression, which is an initial increase followed by a decrease in tumor burden or in the number of tumor lesions. This heterogeneity complicates clinical decisions because either premature withdrawal of the treatment or prolonged ineffective treatment harms patients. We presented two patients treated with ICIs with heterogeneous responses.

An Integrated Pan-Cancer Analysis of ADAMTS12 and Its Potential Implications in Pancreatic Adenocarcinoma.

Background: A Disintegrin and Metallopeptidase with Thrombospondin Type 1 Motif 12 (ADAMTS12), a member of the ADAMTS family of multidomain extracellular protease enzymes, is involved in the progression of many tumors. However, a pan-cancer analysis of this gene has not yet been performed. Its role in pancreatic adenocarcinoma (PAAD) also remains unclear.

Smartphone Sensing of Road Surface Condition and Defect Detection.

Road surface condition is vitally important for road safety and transportation efficiency. Conventionally, road surface monitoring relies on specialised vehicles equipped with professional devices, but such dedicated large-scale road surveying is usually costly, time-consuming, and prohibitively difficult for frequent pavement condition monitoring-for example, on an hourly or daily basis. Current advances in technologies such as smartphones, machine learning, big data, and cloud analytics have enabled the collection and analysis of a great amount of field data from numerous users (e.

Uniform decoration of UiO-66-NH nanooctahedra on TiO electrospun nanofibers for enhancing photocatalytic H production based on multi-step interfacial charge transfer.

Metal-organic framework (MOF) materials have been extensively incorporated with inorganic semiconductor photocatalysts to improve their photocatalytic activity through an efficient charge transfer process across their heterointerface. In this work, octahedral UiO-66-NH2 MOFs with edge-lengths of 110-330 nm are uniformly decorated on the surface of TiO2 electrospun nanofibers by a traditional solvothermal method combined with activation pretreatment. Before the solvothermal growth of UiO-66-NH2, the TiO2 electrospun nanofibers were activated in NaOH solution to etch the TiO2 surface for allowing the exposure of lattice oxygen.

Prognostic Significance of Red Cell Distribution Width in Advanced Non-Small Cell Lung Cancer Patients.

Background: Red blood cell distribution width (RDW) is a parameter reported in blood routine examination, and has been reported as an inflammatory biomarker. The objective of this study was to investigate the significance of RDW in NSCLC patients with EGFR mutations.

Methods: The clinical data of 102 patients with NSCLC who underwent radical resection surgery in the First Affiliated Hospital of Wenzhou Medical University from December 2012 to November 2017 were collected.

Nivolumab plus regorafenib in patients with small bowel adenocarcinoma: A case report.

Introduction: Small bowel adenocarcinomas (SBAs) are rare cancers that have a distinct clinical characteristic and genetic profile. The only potentially curative treatment for localized SBAs is surgery, and treatment options are limited for patients in the advanced stage of disease.

Patient Concerns: A 39-year-old woman presented in October 2015 with a complaint of persistent vomiting for 8 months.

Successful Treatment of Patients with Refractory High-Grade Serous Ovarian Cancer with GOPC-ROS1 Fusion Using Crizotinib: A Case Report.

Background: Recently, multiple poly (ADP-ribose) polymerase (PARP) inhibitors have demonstrated excellent efficacy among patients with ovarian cancer with or without BRCA mutations. However, alternative therapeutic options are urgently required for patients who cannot benefit from conventional chemotherapy or PARP inhibitors.

Case Presentation: A patient with high-grade serous ovarian carcinoma presented to our clinic after developing resistance to chemotherapy.

Synthesis and high pressure studies of white luminescence host-guest complex nanocrystals based on C and p-But-calix[8]arene.

Host-guest structured nanocrystals consisting of p-But-calix[8]arene and fullerene C were fabricated with the facial solution deposition method. The as-prepared host-guest complex nanocrystals are well crystallized in a tetragonal structure, in which the guest C and host p-But-calix[8]arene molecules interact with each other via the van der Waals force. The host-guest crystal has a wider band gap compared to that of C crystals.

Endoplasmic reticulum Ca2+ release causes Rieske iron-sulfur protein-mediated mitochondrial ROS generation in pulmonary artery smooth muscle cells.

Mitochondrial reactive oxygen species (ROS) cause Ca2+ release from the endoplasmic reticulum (ER) via ryanodine receptors (RyRs) in pulmonary artery smooth muscle cells (PASMCs), playing an essential role in hypoxic pulmonary vasoconstriction (HPV). Here we tested a novel hypothesis that hypoxia-induced RyR-mediated Ca2+ release may, in turn, promote mitochondrial ROS generation contributing to hypoxic cellular responses in PASMCs. Our data reveal that application of caffeine to elevate intracellular Ca2+ concentration ([Ca2+]i) by activating RyRs results in a significant increase in ROS production in cytosol and mitochondria of PASMCs.

P27 Promotes TGF--Mediated Pulmonary Fibrosis via Interacting with MTORC2.

Pulmonary fibrosis (PF), a progressive and life-threatening pulmonary disease, is the main pathological basis of interstitial lung disease (ILD) which includes the idiopathic pulmonary fibrosis (IPF). No effective therapeutic strategy for pulmonary fibrosis has been established. TGF- signaling has emerged as the vital regulator of PF; however, the detailed molecular mechanisms of TGF- in PF were uncertain.

Terbium Oxalatophosphonate as Efficient Multiresponsive Luminescent Sensors for Chromate Anions and Tryptophan Molecules.

A stable 2D terbium oxalatophosphonate with green luminescence, namely, [Tb(HL)(CO)(HO)]·2HO (), has been hydrothermally obtained by using (4-carboxypiperidyl)--methylenephosphonic acid (HL) and oxalate ligand. The luminescent investigation indicates that the emission behavior of compound shows high water and pH stabilities. It can be applied as a multiresponsive luminescent probe with high selectivity, high sensitivity, recycling capability, and fast sensing of CrO , CrO anions and tryptophan (Trp) molecules in aqueous solution through the luminescence quenching effect.

Two Highly Stable Luminescent Lead Phosphonates Based on Mixed Ligands: Highly Selective and Sensitive Sensing for Thymine Molecule and VO Anion.

Two luminescent lead phosphonates with two-dimensional (2D) layer and three-dimensional (3D) framework structure, namely, Pb[(L)(Hssc)(HO)] () and [Pb(L)(bts)(HO)]·HO () (HL = O(CHCH)NCHPOH, HL = HPOCHNH(CH)NHCHPOH, Hssc = 5-sulfosalicylic acid, NaHbts = 5-sulfoisophthalic acid sodium) have been prepared via hydrothermal techniques. The two compounds not only show excellent thermal stability but also remain intact in aqueous solution within an extensive pH range. Moreover, the atomic absorption spectroscopy analysis experiment indicates that there does not exist the leaching of Pb ions from the lead phosphonates, which show they are nontoxic in aqueous solution.

High-Efficiency Cryo-Thermocells Assembled with Anisotropic Holey Graphene Aerogel Electrodes and a Eutectic Redox Electrolyte.

Thermocells, capable of converting temperature-dependent electrochemical redox potentials into electrical power, can harvest waste or low-grade heat in an economical and continuous approach with zero carbon emission. However, the power density and conversion efficiency of thermocells are hindered by a narrow operation window and low ion conductivity of the electrodes, especially in freezing weather conditions. Herein, highly efficient cylindrical thermocells, working in a wide operation window of cold temperatures, are developed.

Multiresponsive Graphene-Aerogel-Directed Phase-Change Smart Fibers.

Wearable devices and systems demand multifunctional units with intelligent and integrative functions. Smart fibers with response to external stimuli, such as electrical, thermal, and photonic signals, etc., as well as offering energy storage/conversion are essential units for wearable electronics, but still remain great challenges.

Investigate on Structure and Optical Properties of ZnO Nanostructures Grown on a-GaN/r-Sapphire.

ZnO nanostructures were directly grown on a-GaN/r-sapphire with different growth time via aqueous method. Structural and optical properties of the nanostructures were investigated by using a variety of techniques including X-ray diffraction (XRD), scan electron microscope (SEM), room-temperature photoluminescence (PL), and Raman scattering. The results showed the growth mechanism of ZnO nanostructures grown on a-GaN is Volmer-Weber (VW) mode, which is due to the high interfacial free-energy between a-plane ZnO and GaN.

Efficacy and safety of bevacizumab treatment for refractory brain edema: Case report.

Objective: This retrospective study investigated the efficacy and safety of bevacizumab treatment for refractory brain edema.

Methods: Between March 2009 and December 2015, bevacizumab was used to treat 59 cases of brain metastatic patients with refractory brain edema. The median dose of bevacizumab was 4.

Growth of Indium Hydroxide Nanocubes Film by Hydrothermal Method.

A new strategy has been successfully designed for the first time to synthesize indium hydroxide (In(OH)3) nanocube film by employing a novel hydroxyl (OH−) solution corrosion-base approach. The structure and optical properties of the In(OH)3 structures were investigated. It showed that In(OH)3 cube film structure was formed.

Photoluminescence changes of C nano/submicro-crystals induced by high pressure and high temperature.

Hollow C nano/submicro-crystals with a fcc lattice structure were treated under various high pressure and high temperature conditions. The energy band structure was visibly changed by the high pressure and high temperature treatment, and the luminescence of the treated C nano/submicro-crystals were tuned from the visible to the near infrared range. In-situ high pressure experiments at room temperature indicate that pressure plays a key role in the tuning of the band gap and PL properties in C nanocrystals, and temperature plays an important role in the formation of stable intermolecular bonds and thus to define the final red-shift of the PL peaks.

Direct observation of magnetic vortex behavior in an ordered LaSrMnO dot arrays.

Directly observing the magnetic domain behavior in patterned nanostructures is crucial to the investigation into advanced spin-based devices. Herein, we show that the magnetic vortex behavior can be deterministically observed and controlled in highly spin polarized LaSrMnO (LSMO) triangular dots by successive in-field magnetic force microscopy (MFM). Imaging the magnetic domains with MFM shows that most of the LSMO dots exhibit magnetic vortex states with a clockwise or anticlockwise "pinwheel" structure for decreasing the demagnetization energy.

MicroRNA-381 Negatively Regulates TLR4 Signaling in A549 Cells in Response to LPS Stimulation.

It is widely reported that miR-381 is dysregulated in various tumors. However, the specific role of miR-381 in respiratory infections has not been reported. To probe this role, A549 cells were pretreated with 1 μg/mL LPS for 24 h.

AC driven magnetic domain quantification with 5 nm resolution.

As the magnetic storage density increases in commercial products, e.g. the hard disc drives, a full understanding of dynamic magnetism in nanometer resolution underpins the development of next-generation products.

Stereotactic body radiation therapy for centrally-located lung tumors.

The application of high-dose irradiation to centrally-located lung tumors is generally considered to be of high risk in causing bronchial injury. The aim of the present retrospective study was to investigate the safety and efficacy of stereotactic body radiation therapy (SBRT) for patients with centrally-located lung tumors. In total, 28 patients who underwent SBRT for lung tumors within 2 cm of a major bronchus were retrospectively analyzed.

Slow magnetic relaxation in a cyano-bridged ferromagnetic {Fe(III)Ni(II)} alternating chain.

A cyano-bridged ferromagnetic {Fe(III)Ni(II)} alternating chain {[Fe(pzTp)(CN)3][Ni(chxn)2]}·ClO4·H2O (1) (pzTp = tetrakis(pyrazolyl)borate, chxn = (1R,2R)-1,2-diaminocyclohexane) was synthesized via rational design. Crystal structure analysis and magnetic studies demonstrated that compound had a one-dimensional zigzagging chain-like structure and slow magnetic relaxation.