Predicting the Compressive Strength of Sustainable Portland Cement-Fly Ash Mortar Using Explainable Boosting Machine Learning Techniques.

Unconfined compressive strength (UCS) is a critical property for assessing the engineering performances of sustainable materials, such as cement-fly ash mortar (CFAM), in the design of construction engineering projects. The experimental determination of UCS is time-consuming and expensive. Therefore, the present study aims to model the UCS of CFAM with boosting machine learning methods.

Dynamic Cooperative Communications with Mutual Information Accumulation for Mobile Robots in Industrial Internet of Things.

Mobile robots play an important role in the industrial Internet of Things (IIoT); they need effective mutual communication between the cloud and themselves when they move in a factory. By using the sensor nodes existing in the IIoT environment as relays, mobile robots and the cloud can communicate through multiple hops. However, the mobility and delay sensitivity of mobile robots bring new challenges.

Study on Mechanical and Acoustic Emission Characteristics of Backfill-Rock Instability under Different Stress Conditions.

Unveiling the mechanical properties and damage mechanism of the complex composite structure, comprising backfill and surrounding rock, is crucial for ensuring the safe development of the downward-approach backfill mining method. This work conducts biaxial compression tests on backfill-rock under various loading conditions. The damage process is analyzed using DIC and acoustic emission (AE) techniques, while the distribution of AE events at different loading stages is explored.

Small-scale layered structures at the inner core boundary.

The fine-scale seismic features near the inner core boundary (ICB) provide critical insights into the thermal, chemical, and geodynamical interactions between liquid and solid cores, and may shed light on the evolution mechanism of the Earth's core. Here, we utilize a dataset of pre-critical PKiKP waveforms to constrain the fine structure at the ICB, considering the influence of various factors such as source complexity, structural anomalies in the mantle, and properties at the ICB. Our modeling suggests a sharp ICB beneath Mongolia and most of Northeast Asia, but a locally laminated ICB structure beneath Central Asia, Siberia, and part of Northeast Asia.

N-methyl-d-aspartate receptor 1 activation mediates cadmium-induced epithelial-mesenchymal transition in proximal tubular cells.

Cadmium (Cd) is a commonly found environmental pollutant and is known to damage multiple organs with kidneys being the most common one. N-methyl-d-aspartate receptor 1 (NMDAR1) is a ligand-gated ion channel that is highly permeable to calcium ion (Ca). Because Cd and Ca have structural and physicochemical similarities, whether and how Cd could interfere NMDAR1 function to cause renal epithelial cells dysfunction remains unknown.

The electronic properties of boron-doped germanium nanocrystals films.

Various doping concentrations of boron (B)-doped germanium nanocrystal (Ge NC) films were prepared using the plasma-enhanced chemical vapor deposition (PECVD) technique followed by thermal annealing treatment. The electronic properties of B-doped Ge NCs films combined with the microstructural characterization were investigated. It is worthwhile mentioning that the Hall mobilities [Formula: see text] of Ge NCs films were enhanced after B doping and reached to the maximum of 200 cm V, which could be ascribed to the reduction in surface defects states in the B-doped films.

Integrated mRNA and microRNA profiling in lung tissue and blood from human silicosis.

Background: The overwhelming majority of subjects in the current silicosis mRNA and microRNA (miRNA) expression profile are of human blood, lung cells or a rat model, which puts limits on the understanding of silicosis pathogenesis and therapy. To address the limitations, our investigation was focused on differentially expressed mRNA and miRNA profiles in lung tissue from silicosis patients to explore potential biomarker for early detection of silicosis.

Methods: A transcriptome study was conducted based on lung tissue from 15 silicosis patients and eight normal people, and blood samples from 404 silicosis patients and 177 normal people.

Trajectories of Cognition and Daily Functioning Before and After Incident Diabetes.

Objective: The temporal pattern of cognitive and functional change before and after incident diabetes remains unknown.

Research Design And Methods: Data from wave 2 to wave 9 (2004-2018) of the English Longitudinal Study of Ageing were used. Global cognition (assessed by orientation, memory, and executive function) and daily functioning (calculated as the sum of impaired basic and instrumental activities of daily living) were measured in each wave.

Sirtuin-1 attenuates cadmium-induced renal cell senescence through p53 deacetylation.

Cadmium (Cd), the common environmental pollutant, primarily targets at renal proximal tubules and induces nephrotoxicity. Cellular senescence, a phenomenon of cell growth arrest and a characteristics of maladaptive cell self-repair, is associated with renal disease progression. However, whether and how Cd induces renal tubular cells premature senescence is unknown.

Association of baseline level of cardiovascular risk burden and its temporal changes with cognitive decline.

Background And Aim: Previous studies on cardiovascular risk burden assessed by the Framingham General Cardiovascular Risk Score (FGCRS) and cognitive trajectories mainly focus on Western populations and most of them have used a single measure of cardiovascular risk. In this study, among middle-aged and older Chinese, we investigated (i) the association of baseline FGCRS with subsequent cognitive decline and (ii) the association of FGCRS change with concomitant cognitive decline.

Materials And Methods: In wave 1 to wave 4 (2011-2018) of the China Health and Retirement Longitudinal Study, global cognition was assessed by orientation, memory, and executive function.

Slab control on the mega-sized North Pacific ultra-low velocity zone.

Ultra-low velocity zones (ULVZs) are localized small-scale patches with extreme physical properties at the core-mantle boundary that often gather at the margins of Large Low Velocity Provinces (LLVPs). Recent studies have discovered several mega-sized ULVZs with a lateral dimension of ~900 km. However, the detailed structures and physical properties of these ULVZs and their relationship to LLVP edges are not well constrained and their formation mechanisms are poorly understood.

The effect of different drugs on hard metal lung disease in a rat model.

Hard metal lung disease (HMLD) drugs include dexamethasone sodium phosphate (Dex), methylprednisolone (MP) injection, N-acetylcysteine injection (NAC), and a mix of Dex, MP, and NAC (MIX). In this study, we compared the effects of these drugs on different cytokines of hard metal lung disease in a rat model. Thirty-six adult female Sprague Dawley rats were distributed equally into the control group, hard metal (HM) group, Dex group, MP group, NAC group, and MIX group.

Machine Learning Based Identification of Microseismic Signals Using Characteristic Parameters.

Microseismic monitoring system is one of the effective means to monitor ground stress in deep mines. The accuracy and speed of microseismic signal identification directly affect the stability analysis in rock engineering. At present, manual identification, which heavily relies on manual experience, is widely used to classify microseismic events and blasts in the mines.

Structures, Electronic Properties and Carrier Transport Mechanisms of Si Nano-Crystalline Embedded in the Amorphous SiC Films with Various Si/C Ratios.

Recent investigations of fundamental electronic properties (especially the carrier transport mechanisms) of Si nanocrystal embedded in the amorphous SiC films are highly desired in order to further develop their applications in nano-electronic and optoelectronic devices. Here, Boron-doped Si nanocrystals embedded in the amorphous SiC films were prepared by thermal annealing of Boron-doped amorphous Si-rich SiC films with various Si/C ratios. Carrier transport properties in combination with microstructural characteristics were investigated via temperature dependence Hall effect measurements.

Analysis of Early Biomarkers Associated With Noise-Induced Hearing Loss Among Shipyard Workers.

Importance: It is important to determine what frequencies and auditory perceptual measures are the most sensitive early indicators of noise-induced hearing impairment.

Objectives: To examine whether hearing loss among shipyard workers increases more rapidly at extended high frequencies than at clinical frequencies and whether subtle auditory processing deficits are present in those with extensive noise exposure but little or no hearing loss.

Design, Setting, And Participants: This cross-sectional study collected audiometric data (0.

Identifying genetic risk variants associated with noise-induced hearing loss based on a novel strategy for evaluating individual susceptibility.

Background: The overall genetic profile for noise-induced hearing loss (NIHL) remains elusive. Herein we proposed a novel machine learning (ML) based strategy to evaluate individual susceptibility to NIHL and identify the underlying genetic risk variants based on a subsample of participants with extreme phenotypes.

Methods: Five features (age, sex, cumulative noise exposure [CNE], smoking, and alcohol drinking status) of 5,539 shipbuilding workers from large cross-sectional surveys were included in four ML classification models to predict their hearing levels.

Dual role of inositol-requiring enzyme 1α (IRE-1α) in Cd-induced apoptosis in human renal tubular epithelial cells: Endoplasmic reticulum stress and STAT3 signaling activation.

Cadmium (Cd) is a nephrotoxicant that primarily damages renal proximal tubular cells. Endoplasmic reticulum (ER) stress is mechanistically linked to Cd-induced renal injury. Inositol-requiring enzyme 1 (IRE-1α) is the most conserved ER stress transducer protein, which has both kinase and endonuclease activities.

Efficacy of Beraprost Sodium Combined with Sildenafil and Its Effects on Vascular Endothelial Function and Inflammation in Patients Experiencing Left Heart Failure Complicated with Pulmonary Arterial Hypertension.

BACKGROUND To explore the efficacy of beraprost sodium combined with sildenafil and its effects on the vascular endothelial function and inflammation in left heart failure patients complicated with pulmonary arterial hypertension. MATERIAL AND METHODS A total of 80 patients with left heart failure complicated with pulmonary arterial hypertension was enrolled as the subjects of this study and assigned into an observation group (n=40) and a control group (n=40) using a random number table. The changes in pulmonary arterial hypertension-associated indicators at 3 months after treatment and the alterations in the levels of cardiac function-associated biochemical indicator brain natriuretic peptide (BNP), inflammatory factor tumor necrosis factor alpha (TNF-alpha), and mean pulmonary arterial pressure during treatment were compared between the 2 groups.

Changes in miR-222 expression, DNA repair capacity, and MDM2-p53 axis in association with low-dose benzene genotoxicity and hematotoxicity.

Mechanisms for hematotoxicity and health effects from exposure to low doses of benzene (BZ) remain to be identified. To address the information gap, our investigation was focused onto using appropriate populations and cell cultures to investigate novel BZ-induced effects such as disruption of DNA repair capacity (DRC). From our study, abnormal miRNAs were identified and validated using lymphocytes from 56 BZ-poisoned workers and 53 controls.

A Waveform Image Method for Discriminating Micro-Seismic Events and Blasts in Underground Mines.

The discrimination of micro-seismic events (events) and blasts is significant for monitoring and analyzing micro-seismicity in underground mines. To eliminate the negative effects of conventional discrimination methods, a waveform image discriminant method was proposed. Principal component analysis (PCA) was applied to extract the raw features of events and blasts through their waveform images that established by the recorded field data, and transform them into the new uncorrelated features.

Aberrant lncRNA Profiles Are Associated With Chronic Benzene Poisoning and Acute Myelocytic Leukemia.

Objective: This study investigates the mechanisms of benzene hematotoxicity.

Methods: We used microarray to detect expression profiles of long non-coding RNAs (lncRNAs) and mRNAs in peripheral lymphocytes from chronic benzene poisoning, acute myelocytic leukemia, and healthy controls. The lncRNAs and mRNAs were validated using real-time quantitative PCR (RT-qPCR).

Author Correction: Velocity and density characteristics of subducted oceanic crust and the origin of lower-mantle heterogeneities.

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

Promoter hypermethylation in CSF3R induces peripheral neutrophil reduction in benzene-exposure poisoning.

Benzene is a global pollutant and has been established to cause leukemia. To better understand the role of DNA methylation in benzene toxicity, peripheral blood mononuclear cells were collected from six benzene-poisoning patients and six matched controls for genome-wide DNA methylation screening by Illumina Infinium Methylation 450 BeadChip. The Gene Chip Human Gene 2.

Velocity and density characteristics of subducted oceanic crust and the origin of lower-mantle heterogeneities.

Seismic heterogeneities detected in the lower mantle were proposed to be related to subducted oceanic crust. However, the velocity and density of subducted oceanic crust at lower-mantle conditions remain unknown. Here, we report ab initio results for the elastic properties of calcium ferrite-type phases and determine the velocities and density of oceanic crust along different mantle geotherms.

Study of lung toxicity in rats exposed to silica powder with different hard metal constituents.

The objective of this study was to assess the lung toxicity induced by the inhalation of different hard metal constituents and silica powder and screen for potential toxicity biomarkers. Rats were randomly divided into saline, cobalt, tungsten carbide, silica, and hard metal (HM) groups and were administered a single 10-mg dose of the respective treatments. After 8 weeks, the lung tissue structure in the HM group was deformed, numerous nucleated giant and epithelial-like cells appeared in the stroma, and the computed tomography scanning images appeared abnormal.