Publications by authors named "Daoxin Luo"
Reactive oxygen species (ROS)-responsive ion channels regulate the ion flow across the membranes in response to alterations in the cellular redox state, playing a crucial role in cellular adaptation to oxidative stress. Despite their significance, replicating ROS-responsive functionality in artificial ion channels remains elusive. In this study, we introduce a novel class of artificial H/Cl ion channels activatable by elevated ROS levels in cancer cells.
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- Ceramides, a type of sphingolipid, can self-assemble into adaptable protein channels, a trait that is underexplored in artificial ion channels.
- A new class of artificial channels, called Pn-TPPs, made from PEGylated cholic acids with triphenylphosphonium groups, can form chloride ion channels at low concentrations and nanopores at high concentrations.
- These Pn-TPPs selectively target mitochondria in cancer cells, triggering apoptosis while showing promising anticancer effects, particularly with P5-TPP demonstrating significant activity against liver cancer cells, outperforming doxorubicin in selectivity.