Ecofriendly magnetic nanocomposite (FeO/SiO/Ag) fabrication for sustainable dye wastewater management: catalysis and SERS for a cleaner approach.

Our study focuses on sustainable dye wastewater management through catalysis, scrutinized by surface-enhanced Raman spectroscopy (SERS) using an ecofriendly magnetic nanocomposite (FeO/SiO/Ag (FSA)). To our knowledge, the use of green synthesis for fabricating nanocomposites from a single source, namely Nerium oleander leaves, has not been extensively explored. This poses a distinctive and challenging approach, differentiating it from conventional chemical methods.

Cyanobacteria Lectin (MVL) Interacts with SARS-CoV-2 Spike Protein Receptor Binding Domains (RBDs) via Protein-Protein Interaction.

The emergence of coronavirus disease 2019 (COVID-19) posed a major challenge to healthcare systems worldwide, especially as mutations in the culprit Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) complicated the development of vaccines and antiviral drugs. Therefore, the search for natural products with broad anti-SARS-CoV-2 capabilities is an important option for the prevention and treatment of similar infectious diseases. Lectins, which are widely recognized as antiviral agents, could contribute to the development of anti-SARS-CoV-2 drugs.

Advancing Palliative Care through Advanced Nursing Practice: A Rapid Review.

Objectives: This study addresses the growing demand for palliative care (PC) by exploring the role of advanced nursing practice (ANP) within the multidisciplinary team. The purpose is to outline the background of ANP in PC, its interest, training needs, and some recommendations for its establishment in the Moroccan healthcare system.

Materials And Methods: A rapid review of relevant studies was carried out through databases following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses standards, edition (2020).

Highly flexible copper tape decorated with Ag nanoarrays as ultrasensitive SERS platforms for multi-hazardous pollutant sensing.

A highly flexible and cost-effective copper tape decorated with silver nanoparticles (Cu-TAg) has been developed for surface-enhanced Raman spectroscopy (SERS) sensing of multi-hazardous environmental pollutants. Highly ordered and spherical-shaped silver nanoarrays have been fabricated using a low-cost thermal evaporation method. The structural, morphological, and optical properties of Cu-TAg sensors have been studied and correlated to the corresponding SERS performances.

Highly efficient, label free, ultrafast plasmonic SERS biosensor (silver nanoarrays/Si) to detect GJB2 gene expressed deafness mutations in real time validated with PCR studies.

Rapid diagnostics of any gene mutations related to organ loss is highly demanded now-a days to consume time as well to reduce cost. Currently, Surface enhanced Raman spectroscopy (SERS) is evolved to be a rapid investigating tool to screen gene mutations down to single molecule sensing with regard to the design and development of substrates used for sensing. The current research focuses on particular towards direct detection of deafness mutations associated with single and dual sites related to GJB2 gene.

Diode characteristics, piezo-photocatalytic antibiotic degradation and hydrogen production of Ce doped ZnO nanostructures.

Piezo-photocatalysis of ZnO nanostructures had recently well attracted due to their exceptional potential in degrading the antibiotics and scalable hydrogen production. Here, we have synthesized the Ce doped ZnO nanospheres in a facile wet chemical strategy. Dopant ions induced morphological evolution and optical bandgap tuning had observed in our experiment.

A Metalloproteinase Cocktail from the Venom of Cleaves Amyloid Beta Peptides at the α-Cleavage Site.

A disintegrin and metalloproteinase (ADAM) family proteins are a major class of membrane-anchored multidomain proteinases that are responsible for the shedding of cell surface protein ectodomains, including amyloid precursor protein (APP). Human ADAM 9, 10, and 17 proteolyze APPs and produce non-amyloid-genic p3 peptides, instead of neurotoxic amyloid-β peptides (Aβs; Aβ40 and Aβ42), which form fibrils and accumulate in the brain of patients with Alzheimer's disease (AD). The ADAM family is closely related to snake venom metalloproteinases (SVMPs), which are derived from ancestral ADAMs but act as soluble proteinases.

Multi-functional silver nanoprism-titanium dioxide hybrid nanoarrays for trace-level SERS sensing and photocatalytic removal of hazardous organic pollutants.

Owing to the excellent optoelectronic properties of metal nanoparticle-semiconductor interfaces; hybrid substrates with superior catalytic and sensing properties can be designed. In the present study, we have attempted to evaluate anisotropic silver nanoprisms (SNP) functionalized titanium dioxide (TiO) particles for multifunctional applications such as SERS sensing and photocatalytic decomposition of hazardous organic pollutants. Hierarchical TiO/SNP hybrid arrays have been fabricated via facile and low-cost casting techniques.

Speech acoustic indices for differential diagnosis between Parkinson's disease, multiple system atrophy and progressive supranuclear palsy.

While speech disorder represents an early and prominent clinical feature of atypical parkinsonian syndromes such as multiple system atrophy (MSA) and progressive supranuclear palsy (PSP), little is known about the sensitivity of speech assessment as a potential diagnostic tool. Speech samples were acquired from 215 subjects, including 25 MSA, 20 PSP, 20 Parkinson's disease participants, and 150 healthy controls. The accurate differential diagnosis of dysarthria subtypes was based on the quantitative acoustic analysis of 26 speech dimensions related to phonation, articulation, prosody, and timing.

Anti-Cancer Activity of Venom on Hepatocellular Carcinoma in 3D Cell Culture.

Hepatocellular carcinoma (HCC) is the most dominant primary liver cancer, which can be caused by chronic hepatitis virus infections and other environmental factors. Resection, liver transplantation, and local ablation are only a few of the highly effective and curative procedures presently accessible. However, other complementary treatments can reduce cancer treatment side effects.

Induced pathophysiological alterations by the venoms of the most dangerous Moroccan scorpions and : A comparative pathophysiological and toxic-symptoms study.

Scorpion envenomation is a serious public health issue.  () and  () are the most dangerous scorpions in Morocco. Despite their medical relevance, no study has yet related their kinetics of symptom apparition and the consequent tissue disorders at the same interval post-injection.

Ultra-sensitive and fast optical detection of the spike protein of the SARS-CoV-2 using AgNPs/SiNWs nanohybrid based sensors.

Severe acute respiratory syndrome SARS-CoV-2 virus led to notable challenges amongst researchers in view of development of new and fast detecting techniques. In this regard, surface-enhanced Raman spectroscopy (SERS) technique, providing a fingerprint characteristic for each material, would be an interesting approach. The current study encompasses the fabrication of a SERS sensor to study the SARS-CoV-2 S1 (RBD) spike protein of the SARS-CoV-2 virus family.

Anti-Cancer Effect of Moroccan Cobra Venom and Its Fractions against Hepatocellular Carcinoma in 3D Cell Culture.

Hepatocellular carcinoma (HCC) is the most common primary liver cancer in adults, the fifth most common malignancy worldwide and the third leading cause of cancer related death. An alternative to the surgical treatments and drugs, such as sorafenib, commonly used in medicine is necessary to overcome this public health problem. In this study, we determine the anticancer effect on HCC of Moroccan cobra venom and its fraction obtained by gel filtration chromatography against Huh7.

Mass spectrometry-based top-down and bottom-up approaches for proteomic analysis of the Moroccan Buthus occitanus scorpion venom.

Buthus occitanus (B. occitanus) is one of the most dangerous scorpions in the world. Despite the involvement of B.

Photoacoustic and high-frequency ultrasound imaging of systemic sclerosis patients.

Introduction: Systemic sclerosis starts with an early phase characterized by Raynaud's phenomenon, puffy fingers/hands, autoantibodies, and a scleroderma nailfold microscopic pattern. Alterations in the nailfold microscopic pattern are not evident in all early SSc patients. Photoacoustics (PA) and high-frequency ultrasound (HFUS) could fulfill this need.

Structural effects of silver-nanoprism-decorated Si nanowires on surface-enhanced Raman scattering.

Surface enhanced Raman scattering (SERS) is an important analytical tool for the optochemical detection of molecules. The enhancement is commonly achieved by engineering (i) novel types and morphologies of plasmonic nanomaterials, and (ii) patterned or roughened supporting substrates of high surface area for increased light scattering and molecule adsorption. Si substrates can be easily and reproducibly textured for effective SERS applications.

A Fourier approach to Lagrangian vortex detection.

We study the transport properties of coherent vortices over a finite-time duration. Here, we reveal that such vortices can be identified based on the frequency-domain representation of Lagrangian trajectories. We use Fourier analysis to convert particles' trajectories from their time domain to a presentation in the frequency domain.

Surface mixing and biological activity in the North-West African upwelling.

Near-shore water along the North-West African margin is one of the world's major upwelling regions. It is associated with physical structures of oceanic fronts which influence the biological productivity. The study of these coherent structures in connection with chlorophyll concentration data is of fundamental importance for understanding the spatial distributions of the plankton.

Feasibility of photoacoustic/ultrasound imaging of synovitis in finger joints using a point-of-care system.

We evaluate a portable ultrasound and photoacoustic imaging (PAI) system for the feasibility of a point-of-care assessment of clinically evident synovitis. Inflamed and non-inflamed proximal interphalangeal joints of 10 patients were examined and compared with joints from 7 healthy volunteers. PAI scans, ultrasound power Doppler (US-PD), and clinical examination were performed.

photoacoustics and high frequency ultrasound imaging of mechanical high intensity focused ultrasound (HIFU) ablation.

The thermal effect of high intensity focused ultrasound (HIFU) has been clinically exploited over a decade, while the mechanical HIFU is still largely confined to laboratory investigations. This is in part due to the lack of adequate imaging techniques to better understand the pathological and immunological effects caused by the mechanical treatment. In this work, we explore the use of high frequency ultrasound (US) and photoacoustics (PA) as a potential tool to evaluate the effect of mechanical ablation , e.

Consequences of and scorpion venoms on electrolyte levels in rabbits.

() and () scorpions, which belong to the family, are the most venomous scorpions in Morocco. For the first time, we investigated the effects of such scorpion venoms on serum electrolytes in subcutaneously injected rabbits. For this purpose, 3 groups of 6 albinos adult male rabbits (New Zealand) were used in this experiment.