Publications by authors named "Daolong Xie"
Ubiquitin-specific proteases (UBPs), the largest subfamily of deubiquitinating enzymes (DUBs), are critical for plant growth and development as well as abiotic-stress responses. In this study, we discovered that the expression of the () gene of the gene () was induced by salt, mannitol and abscisic acid (ABA) treatments. Further research revealed that UBP15 is involved in modulation of salt, drought tolerance and ABA signaling during seed germination, early seedling development, post-germination root growth or adult-plant stage.
View Article and Find Full Text PDFAptamer-drug conjugates-loaded bacteria for pancreatic cancer synergistic therapy.
Signal Transduct Target Ther
October 2024
Article Synopsis
- * The instability of nucleic acid drugs in the body and the dense stroma of pancreatic tumors hinder effective treatment, but a modified Salmonella strain, VNP20009, may be used to deliver ApDC directly to tumors.
- * The proposed method enhances drug stability and targeting, leading to increased drug concentration at tumor sites, improved bacterial colonization, and better tumor cell death, especially when combining chemotherapy and immunotherapy for a synergistic effect.
Background: Mainland China, the world's most populous region, experienced a large-scale coronavirus disease 2019 (COVID-19) outbreak in 2020 and 2021, respectively. Existing infodemiology studies have primarily concentrated on the prospective surveillance of confirmed cases or symptoms which met the criterion for investigators; nevertheless, the actual impact regarding COVID-19 on the public and subsequent attitudes of different groups towards the COVID-19 epidemic were neglected.
Methods: This study aimed to examine the public web-based search trends and behavior patterns related to COVID-19 outbreaks in mainland China by using hot words and Baidu Index (BI).