Facile synthesis of silver nanoclusters for promoting highly sensitive surface-enhanced Raman scattering detection of alkyne-tagged biomolecules.

We synthesized two novel silver-based nanocluster materials (TOS-Ag NCs and TNS-Ag NCs) that were used as SERS substrates, combining the powerful adsorption capability and aggregation effect of silver-sulfur clusters to achieve a highly sensitive identification and detection of alkyne-tagged molecules in the Raman-silent region. This work provides new insights for designing novel nanoclusters as SERS substrates displaying ultrahigh sensitive detection of alkyne-tagged molecules.

4-{Eth-yl[(E)-4-(4-pyridylvin-yl)phenyl]-amino}benzaldehyde.

In the title mol-ecule, C(22)H(20)N(2)O, the central aromatic ring forms dihedral angles of 45.30 (2) and 69.43 (2)°, respectively, with the outer pyridine and benzene rings.