Publications by authors named "Daofan Sun"
In an era where patient-centred care is paramount, effectively managing and analyzing hospital complaints is crucial for improving service quality and patient satisfaction. This study examines hospital complaints to enhance management practices by differentiating between surgery-related and non-surgery-related grievances. By identifying patterns in complaint types and outcomes, we aim to inform targeted quality improvement strategies that address specific patient concerns and boost operational efficiency.
View Article and Find Full Text PDFAims: This study was designed to investigate the role of pericytes in the pathogenesis of perioperative neurocognitive disorder (PND).
Methods: In this study, we established a PND model via sevoflurane anesthesia and tibial fracture surgery in 2-month-old and 16-month-old male C57BL/6 mice. On the third postoperative day, the mice were subjected to behavioral testing or sacrificed to collect brain tissue.
Article Synopsis
- People with chronic pain often feel depressed, but it's not clear how these two problems are connected or how to treat them.
- A study showed that using oxytocin, which can be given as a nasal spray, helped reduce depression-like symptoms in mice with pain from nerve injury, although it didn't help their pain.
- The research suggests that oxytocin works in the brain to help with depression related to pain, making it possible that it could be a useful treatment for people suffering from both issues.
Background: Older individuals have been reported to suffer from cognitive disorders after surgery. Various types of surgical trauma have been used to establish postoperative cognitive dysfunction (POCD) animal models in preclinical studies. However, few comparative analyses of these animal models were conducted.
View Article and Find Full Text PDFSeveral studies have demonstrated that neuroinflammation is the key to perioperative neurocognitive disorders (PND); however, the specific mechanism postsurgery and anesthesia has not yet been fully clarified. The present study is aimed at exploring the effects of P2X4/NLRP3 signaling pathway in neuroinflammation and cognitive impairment after surgery. 12-14-month-old male C57BL/6 mice undergoing open tibial fracture surgery by sevoflurane anesthesia were administered P2X4R inhibitor 5-BDBD or saline was intraperitoneally for 3 consecutive days after surgery.
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