Publications by authors named "Daobo Fan"
Article Synopsis
- Spinal cord injury (SCI) leads to significant neuroinflammation and cell death, worsening neurological functions, but current treatments are ineffective, creating a need for new therapies.
- This study investigates Cynarin, a natural compound found in artichokes, for its potential to reduce neuroinflammation and promote recovery in SCI using a mouse model and cell line experiments.
- Results showed that Cynarin treatment lowers neuroinflammation and microglial cell death, improves locomotor function, and works by inhibiting harmful protein complexes through Nrf2 activation, suggesting it could be a promising treatment for SCI-related complications.
Analysis of the Effect of Percutaneous Cone Shaping in Patients with Osteoporotic Vertebral Fractures.
Contrast Media Mol Imaging
August 2022
Objective: To study and analyze the clinical effect of percutaneous cone shaping in patients with osteoporotic vertebral fractures.
Methods: A total of 100 patients with vertebral osteoporotic fracture treated in our hospital from June 2019 to September 2020 were selected, and there were 50 patients with vertebral osteoporotic fracture in each group. Patients could be divided into two groups according to different treatment plans: one group was vertebroplasty patients for group A, and the other group was nonsurgical treatment patients for group B.
This study aimed to evaluate the effect of intraarticular injection with platelet-rich plasma on knee osteoarthritis. A total of 250 patients with stages I-III osteoarthritis from December 2018 to June 2020 were included in this study. All the patients had received autologous PRP injection (3 ml) into the affected knee joint every week for totally 3 injections.
View Article and Find Full Text PDFMacrophage-dominated inflammation by the activation of Toll-like receptor (TLR) pathway leads to neurological disruption after spinal cord injury (SCI). Regulator of G-protein signaling 1 (RGS1) is reported to be a regulator in inflammation. The present study thus purposes to identify the unknown role of RGS1 mediating TLR on inflammation post SCI.
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