Resveratrol induces apoptosis in pancreatic cancer cells.

Background: Pancreatic cancer is one of the most lethal human cancers with a very low survival rate of 5 years. Conventional cancer treatments including surgery, radiation, chemotherapy or combinations of these show little effect on this disease. Several proteins have been proved critical to the development and the progression of pancreatic cancer.

[Production and identification of monoclonal antibody against human S100A4.].

Aim: To prepare specific monoclonal antibody against human S100A4 protein and establish a reliable method to detect S100A4 protein in tumor specimens.

Methods: A standard hybridoma method was used to generate monoclonoal antibodies against recombinant human S100A4. ELISA, Western blot and immunohistochemistry were used to validate this antibody and the antibody is used to examine specimens of human breast and colon cancers.

hTERT-targeted E. coli purine nucleoside phosphorylase gene/6-methylpurine deoxyribose therapy for pancreatic cancer.

Background: Pancreatic cancer is one of the most common tumors and has a 5-year survival for all stages of less than 5%. Most patients with pancreatic cancer are diagnosed at an advanced stage and therefore are not candidates for surgical resection. In recent years, investigation into alternative treatment strategies for this aggressive disease has led to advances in the field of gene therapy for pancreatic cancer.