A novel bioreactor to simulate urinary bladder mechanical properties and compliance for bladder functional tissue engineering.

Background: Bioreactors are pivotal tools for generating mechanical stimulation in functional tissue engineering study. This study aimed to create a bioreactor that can simulate urinary bladder mechanical properties, and to investigate the effects of a mechanically stimulated culture on urothelial cells and bladder smooth muscle cells.

Methods: We designed a bioreactor to simulate the mechanical properties of bladder.