Publications by authors named "Dao-Min Lu"
Article Synopsis
- This study aimed to compare the effectiveness and safety of adalimumab (ADA) with a herbal remedy called Tripterygium wilfordii (TwHF) against ADA combined with methotrexate (MTX) for patients with rheumatoid arthritis (RA) who did not respond well to MTX.
- Conducted with 64 RA patients, the trial included a treatment group (ADA + TwHF) and a control group (ADA + MTX), monitoring outcomes over 24 weeks for low disease activity and remission rates.
- Results showed no significant differences in efficacy or safety between the two treatment options, indicating that TwHF could be a viable alternative for RA patients who cannot
Jinwujiangu Capsule Treats Fibroblast-Like Synoviocytes of Rheumatoid Arthritis by Inhibiting Pyroptosis via the NLRP3/CAPSES/GSDMD Pathway.
Evid Based Complement Alternat Med
November 2021
Jinwujiangu capsule (JWJGC) is a traditional Chinese medicine formula used to treat rheumatoid arthritis (RA). However, whether its mechanism is associated with pyroptosis remains unclear. In this study, the ability of JWJGC to inhibit the growth of fibroblast-like synoviocytes of RA (RA-FLS) through pyroptosis was evaluated.
View Article and Find Full Text PDF[Effects of Jinwu Jiangu recipe on IL-17/STAT3 signals in rheumatoid arthritis synoviocytes].
Zhongguo Zhong Yao Za Zhi
February 2018
This paper aimed to investigate the effects of Jinwu Jiangu recipe total extract on the IL-17/STAT3 signals in rheumatoid arthritis synovial fibroblasts(RASF). The primary RASFs were cultured by tissue piece method ， and divided into blank control group， Jinwu Jiangu recipe low dose group， Jinwu Jiangu recipe middle dose group， Jinwu Jiangu recipe high dose group， and tripterygium glycosides control group. They were then treated with corresponding serum free medium， different doses of Jinwu Jiangu recipe total extract(0.
View Article and Find Full Text PDF[Effect of Jinwu Jiangu Recipe on Expressions of NF-kappaB and IL-17 in Collagen Induced Arthritis Model Rats].
Zhongguo Zhong Xi Yi Jie He Za Zhi
May 2016
Objective: To explore the effect of Jinwu Jiangu Recipe (JJR) on the expression of synovial cells' nuclear factor-kappaB (NF-kappaB) and serum interleukin 17 (IL-17) in collagen induced arthritis (CIA) rats.
Methods: Totally 60 Wistar rats were randomly divided into 6 groups, i.e.