Publications by authors named "Dao-Kang Xiang"
Pulmonary arterial hypertension (PAH) seriously threatens the elder people. Long non-coding RNAs (lncRNAs) are involved in multiple diseases. However, the study of the lncRNAs in the occurrence of PAH is just beginning.
View Article and Find Full Text PDFBackground/aims: In recent years, microRNA-495 (miR-495) has been reported to be a tumor-suppressor miR that is down-modulated in cancers. However, its potential mechanism remains unknown. Therefore, this study aimed to demonstrate the role of miR-495 in cardiac microvascular endothelial cell (CMEC) injury and inflammatory reaction by mediating the pyrin domain-containing 3 (NLRP3) inflammasome signaling pathway.
View Article and Find Full Text PDFSpontaneous Giant Ascending Aortic Pseudoaneurysm in a Previously Healthy Man.
JACC Cardiovasc Interv
August 2016
[Clinical applications of dosing algorithm in the predication of warfarin maintenance dose].
Zhonghua Yi Xue Za Zhi
December 2011
Objective: To evaluate the feasibility of clinical application for genetic based dosing algorithm in the predication of warfarin maintenance dose in Chinese population.
Methods: The clinical data were collected and blood samples harvested from a total of 126 patients undergoing heart valve replacement. The genotypes of VKORC1 and CYP2C9 were determined by melting curve analysis after PCR.
[Impact of five genetic polymorphisms on inter-individual variation in warfarin maintenance dose].
Zhonghua Yi Xue Yi Chuan Xue Za Zhi
December 2011
Objective: To investigate the effect of genetic polymorphisms in VKORC1, CYP2C9, GGCX, EPHX1, APOE genes on inter-individual variation in warfarin maintenance dose.
Methods: Two hundred and forty-nine patients with stable warfarin dose were enrolled in this study, and the clinical data and blood samples of the patients were collected. Genotypes for the 5 genes were determined by using PCR and denaturing high performance liquid chromatography (DHPLC) assay.
Article Synopsis
- * Researchers analyzed 217 patients, identifying genotypes and comparing their warfarin doses using various statistical methods, finding that the GGCX 3261AA genotype required a higher average daily maintenance dose.
- * The results indicate that the GGCX 3261G>A variation accounts for a small but significant portion (2.3%) of the variance in warfarin dosing needs among the patients studied.
Objectives: To develop a warfarin-dosing algorithm that could be combined with pharmacogenomic and demographic factors, and to evaluate its effectiveness in a randomized prospective controlled clinical trial.
Methods: A pharmacogenetics-based dosing model was derived using retrospective data from 266 Chinese patients and multiple linear regression analysis. To prospectively validate this model, 156 patients with an operation of heart valve replacement were enrolled and randomly assigned to the group of pharmacogenetics-guided or traditional dosing for warfarin therapy.
Objective: To investigate the myocardial protective effect of L-carnitine as an ingredient of cardiac arresting solution in the process of heart valve replacement operation.
Methods: 69 cases undergoing heart valve replacement with cardiopulmonary bypass (CPB), 47 males and 22 females, aged 48.17 +/- 14.