IL-37 Inhibits Inflammation of Lacrimal Gland in Dry Eye Mice via the IL-37-PTEN-NFκB Signaling Pathway.

Purpose: This study aims to investigate the role of Interleukin-37 (IL-37) in mouse models of dry eye.

Methods: Two murine models of dry eye were employed in this investigation.   The evaluation of the anti-inflammatory impact of IL-37 (200 μl, 10 μg/ml) on dry eye mice involved intraperitoneal injections administered once daily for 7 days.

ER-1 deficiency induces inflammation and lipid deposition in meibomian gland and lacrimal gland.

Purpose: To investigated the role of estrogen receptor-1 (ER-1) in maintaining homeostasis in ocular surface.

Methods: ER-1-knockout (ER-1KO) mice were studied at 4 months of age. The ocular surface was examined using a slit lamp.