An MXene-supported NHCNT and BiOCl composite as a sulfur reservoir for Li-S batteries with high energy density.

To solve the intractable challenges of Li-S batteries, we synthesized MXene-NHCNT-BiOCl- to be used as a sulfur host. The M-N-B-10%-S electrode exhibited superior electrochemical performance. XRD measurement confirmed that the M-N-B-10%-S electrode displayed good cycle stability.

Enhancing tylosin production by combinatorial overexpression of efflux, SAM biosynthesis, and regulatory genes in hyperproducing strain.

Tylosin is a 16-membered macrolide antibiotic widely used in veterinary medicine to control infections caused by Gram-positive pathogens and mycoplasmas. To improve the fermentation titer of tylosin in the hyperproducing strain TL01, we sequenced its whole genome and identified the biosynthetic gene cluster therein. Overexpression of the tylosin efflux gene , the luster-ituated -adenosyl methionine (SAM) synthetase gene , the SAM biosynthetic genes -, or the pathway-specific activator gene enhanced tylosin production by 18%, 12%, 11%, and 11% in the respective engineered strains TLPH08-2, TLPH09, TLPH10, and TLPH12.

Breast-conserving surgery and sentinel lymph node biopsy for breast cancer and their correlation with the expression of polyligand proteoglycan-1.

Background: Breast cancer is a malignant tumor with an unclear etiology and is the most common malignant tumor in women. Surgery is the main clinical treatment for breast cancer. Although traditional total mastectomy combined with axillary lymph node dissection is effective, it can result in shoulder dysfunction, especially in middle-aged and elderly patients with breast cancer with weak constitution and other underlying diseases.

EZH2, a prominent orchestrator of genetic and epigenetic regulation of solid tumor microenvironment and immunotherapy.

Immune checkpoint blockade (ICB) is regarded as a promising strategy for cancer therapy. The histone methyltransferase, Enhancer of Zeste Homolog 2 (EZH2), has been implicated in the carcinogenesis of numerous solid tumors. However, the underlying mechanism of EZH2 in cancer immunotherapeutic resistance remains unknown.

High FAS expression correlates with a better prognosis and efficacy of taxanes and target regents in breast cancer.

Background: FAS can serve as both an oncogene and a suppresser in different malignancies, and the prognostic value of FAS remains controversial.

Methods: The Oncomine database, KM-Plotter and bc-GenExMiner platform were adopted to analyze the prognostic value of FAS in breast cancer. Breast cancer tissue microarrays were further used to verify these data.

miR-301b-3p Regulates Breast Cancer Cell Proliferation, Migration, and Invasion by Targeting NR3C2.

Objectives: Breast cancer is the most common malignant tumor among females, and miRNAs have been reported to play an important regulatory role in breast cancer progression. This study aimed to explore the function and underlying molecular mechanism of miR-301b-3p in breast cancer.

Methods: Differential analysis and survival analysis were performed based on the data accessed from the TCGA-BRCA dataset for identification of the target miRNA.

The Progress and Prospect of Tunable Organic Molecules for Organic Lithium-Ion Batteries.

Compared to inorganic electrodes, organic materials are regarded as promising electrodes for lithium-ion batteries (LIBs) due to the attractive advantages of light elements, molecular-level structural design, fast electron/ion transferring, favorable environmental impacts, and flexible feature, Not only specific capacities but also working potentials of organic electrodes are reasonably tuned by polymerization, electron-donating/withdrawing groups, and multifunctional groups as well as conductive additives, which have attracted intensive attention. However, organic LIBs (OLIBs) are also facing challenges on capacity loss, side reactions, electrode dissolution, low electronic conductivity, and short cycle life, Many strategies have been applied to tackle those challenges, and many inspiring results have been achieved in the last few decades. In this review, we have introduced the basic concepts of LIBs and OLIBs, followed by the typical cathode and anode materials with various physicochemical properties, redox reaction mechanisms, and evolutions of functional groups.

An ERP Study on the Auditory Stream Segregation in Cochlear Implant Simulations: Effects of Frequency Separation and Time Interval.

Auditory stream segregation is an important function of the auditory system, and the extent to which this function works has a major impact on listener's ability to recognize auditory objects in complex listening environments. However, cochlear implant (CI) listeners are poorly equipped for this challenge, mainly owing to the impoverished sensory information available via their implants. The purpose of this study was to examine two factors, i.

Studying the Effect of Carrier Type on the Perception of Vocoded Stimuli via Mismatch Negativity.

Vocoder processing has been long used in many studies to examine how acoustic cues affect speech understanding and auditory processing. Early behavioral studies have shown that the type of carrier (i.e.

Factors affecting the intelligibility of high-intensity-level-based speech.

The present work examined factors affecting the intelligibility of high-intensity-level-based speech. Mandarin sentences were processed to contain only high-intensity segments confined by a 5-dB selected intensity range (SIR), with other segments replaced by noise. The processed stimuli were presented to normal-hearing listeners to recognize.

An ERP Study on the Combined-stimulation Advantage in Vocoder Simulations.

Electric hearing is presently the only treatment solution for patients with profound-to-severe hearing loss. For those patients also preserving low-frequency residual hearing on the ipsilateral ear, combined electric-and-acoustic stimulation (EAS) could notably improve their speech understanding abilities relative to those aided with electric-only (E-only) hearing. Early behavioral studies have consistently shown the advantage of combined stimulation.