Publications by authors named "Danyi Zeng"

Background: Due to the high-risk nature of sepsis, emergency departments urgently need a simple evaluation method to assess the degree of inflammation and prognosis in sepsis patients, providing a reference for diagnosis and treatment.

Objective: To investigate the prognostic value of the neutrophil-to-lymphocyte ratio (NLR) combined with the blood urea nitrogen-to-serum albumin ratio (BAR) in sepsis.

Methods: A total of 377 sepsis patients admitted to Lishui People's Hospital from June 2022 to June 2023 were selected as the study subjects.

View Article and Find Full Text PDF

Excessive deposition of monosodium urate (MSU) crystal in the joint results in gout arthritis, which triggers severe pain and affects life quality. Oxidative stress is a pivotal mechanism that contributes to etiology of gout pain and inflammation. Here we investigated whether activating Nrf2, which plays important roles in regulating endogenous antioxidant response, would attenuate gout arthritis via promoting antioxidant signaling in joint tissues.

View Article and Find Full Text PDF
Article Synopsis
  • - Traditional Chinese Medicine (TCM) is being investigated for its potential to help with liver issues related to chronic hepatitis B, but its effectiveness on HBsAg seroclearance is still not well understood.
  • - In a study, mice were treated with specific TCM granules to see their impact on M1 macrophage polarization and HBsAg levels, and a special TCM formula was developed based on the most effective granules.
  • - The findings indicated that the TCM formula improved HBsAg seroclearance, likely by promoting M1 macrophage activity and altering gut microbiota, particularly increasing the presence of Alloprevotella.
View Article and Find Full Text PDF

Background: Gout results from disturbed uric acid metabolism, which causes urate crystal deposition in joints and surrounding tissues. Gout pain management is largely limited to colchicine and nonsteroidal anti-inflammatory drugs. Constant usage of these medications leads to severe side effects.

View Article and Find Full Text PDF

Background: Coronavirus disease (COVID-19) patients exhibit different patterns of liver impairment, according to growing evidence.

Aim: In this study, we sought to provide a comprehensive analysis of liver test parameters in patients with severe and non-severe COVID-19.

Methods: We performed a meta-analysis of published liver manifestations and described the liver damage in COVID-19.

View Article and Find Full Text PDF

Background: Primary liver cancer (PLC) is a major contributor to cancer-related deaths. Data on global and country-specific levels and trends of PLC are essential for understanding the effects of this disease and helping policymakers to allocate resources.

Aim: To investigate the association between the burden of PLC and socioeconomic development status.

View Article and Find Full Text PDF

Background: Chronic postsurgical pain (CPSP) is common among patients receiving major surgeries. CPSP produces suffering in patients, both physically and mentally. However, the mechanisms underlying CPSP remain elusive.

View Article and Find Full Text PDF

Objectives: This study aimed to evaluate the expression of cytosine monophosphate kinase 2 (CMPK2) and activation of the NLRP3 inflammasome in rats with spinal cord injury (SCI) and to characterize the effects of electroacupuncture on CMPK2-associated regulation of the NLRP3 inflammasome.

Methods: An SCI model was established in Sprague-Dawley (SD) rats. The expression levels of NLRP3 and CMPK2 were measured at different time points following induction of SCI.

View Article and Find Full Text PDF

Background: Allergic contact dermatitis (ACD) is a common skin condition characterized by contact hypersensitivity to allergens, accompanied with skin inflammation and a mixed itch and pain sensation. The itch and pain dramatically affects patients' quality of life. However, still little is known about the mechanisms triggering pain and itch sensations in ACD.

View Article and Find Full Text PDF

Background: Mirror-image pain (MIP), which develops from the healthy body region contralateral to the actual injured site, is a mysterious pain phenomenon accompanying many chronic pain conditions, such as complex regional pain syndrome (CRPS). However, the pathogenesis of MIP still remains largely unknown. The purpose of this study is to perform an expression profiling to identify genes related to MIP in an animal model of CRPS-I.

View Article and Find Full Text PDF
Article Synopsis
  • Acute viral hepatitis (AVH) is a significant global health issue, yet research focuses more on chronic infections like HBV and HCV; understanding the burden of AVH is essential for creating global intervention strategies.
  • The study analyzed data from the Global Burden of Disease (GBD) 2019 on acute hepatitis A, B, C, and E, revealing high incidence rates in low socio-demographic index (SDI) regions, especially in West and East Africa.
  • Findings indicate a correlation between lower socioeconomic status and higher AVH burden, suggesting that policymakers should leverage GBD 2019 data for effective interventions.
View Article and Find Full Text PDF

Background: Paclitaxel is a widely prescribed chemotherapy drug for treating solid tumors. However, paclitaxel-induced peripheral neuropathy (PIPN) is a common adverse effect during paclitaxel treatment, which results in sensory abnormalities and neuropathic pain among patients. Unfortunately, the mechanisms underlying PIPN still remain poorly understood.

View Article and Find Full Text PDF

Complex regional pain syndrome type-I (CRPS-I) is chronic neurological disorder accompanied with devastating pain. Most conventional medical treatments lack effectiveness, making CRPS-I a challenging clinical condition. Electroacupuncture (EA) showed effectiveness in alleviating the pain symptoms of CRPS-I patients.

View Article and Find Full Text PDF
Article Synopsis
  • A meta-analysis of 19 studies involving 4,103 COVID-19 patients investigated the link between liver damage and clinical outcomes, revealing distinct liver chemistry patterns for those who died versus those discharged alive.
  • Patients who died showed higher levels of alanine aminotransferase and aspartate aminotransferase, and displayed lower albumin levels, longer prothrombin times, and higher international normalized ratios compared to survivors.
  • The study categorized liver impairment into three types: hepatocellular injury, cholestasis, and hepatocellular dysfunction, emphasizing the need for careful monitoring of liver function in COVID-19 patients.
View Article and Find Full Text PDF

A PHP Error was encountered

Severity: Notice

Message: fwrite(): Write of 34 bytes failed with errno=28 No space left on device

Filename: drivers/Session_files_driver.php

Line Number: 272

Backtrace:

A PHP Error was encountered

Severity: Warning

Message: session_write_close(): Failed to write session data using user defined save handler. (session.save_path: /var/lib/php/sessions)

Filename: Unknown

Line Number: 0

Backtrace: