Publications by authors named "Danyelle Paine"
Article Synopsis
- Constitutional mismatch repair deficiency (CMMRD) is a syndrome that increases the risk of high-grade gliomas in children, leading to poor outcomes and making treatment challenging.* -
- This study evaluates the effectiveness of the histone deacetylase inhibitor, quisinostat, on a hypermutant pediatric high-grade glioma model, showing it causes significant tumor regression and alters gene expression.* -
- The findings suggest quisinostat’s potential as a treatment option for hypermutant DIPG and indicate that loss of mismatch repair function may enhance sensitivity to this drug, encouraging further research on HDAC inhibitors for similar cancers.*
HMG-CoA reductase inhibitors (or statins) are cholesterol-lowering drugs and are among the most widely prescribed medications in the United States. Statins exhibit pleiotropic effects that extend beyond cholesterol reduction including anti-atherosclerotic, antiproliferative, anti-inflammatory, and antithrombotic effects. Over the last 20 years, statins have been studied and examined in pulmonary vascular disorders, including both chronic pulmonary vascular disease such as pulmonary hypertension, and acute pulmonary vascular endothelial injury such as acute lung injury.
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