The present work evaluated the chemical composition and antiulcerogenic potential of the crude extract, fractions and pure compounds isolated of roots barks from Maytenus robusta Reiss, using different pharmacological models in mice. 3,12-Dioxofriedelane (1) and 11-hydroxylup-20 (29)-en-3-one (2) were isolated from the n-hexane fraction, and mayteine (3) and 3,7-dioxofriedelane (4) from the dichloromethane fraction. The crude extract (50, 259, 500 mg/kg), all the fractions (250 mg/kg) and cimetidine (100 mg/kg) significantly reduced the lesion index, total lesion area, and percentage of lesions, in comparison with the control group (p < 0.
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