Caffeine improves mitochondrial dysfunction in the white matter of neonatal rats with hypoxia-ischemia through deacetylation: a proteomic analysis of lysine acetylation.

Aims: White matter damage (WMD) is linked to both cerebral palsy and cognitive deficits in infants born prematurely. The focus of this study was to examine how caffeine influences the acetylation of proteins within the neonatal white matter and to evaluate its effectiveness in treating white matter damage caused by hypoxia-ischemia.

Main Methods: We employed a method combining affinity enrichment with advanced liquid chromatography and mass spectrometry to profile acetylation in proteins from the white matter of neonatal rats grouped into control (Sham), hypoxic-ischemic (HI), and caffeine-treated (Caffeine) groups.

Associations between gut microbiota and adverse neurodevelopmental outcomes in preterm infants: a two-sample Mendelian randomization study.

Gut microbiota are associated with adverse neurodevelopmental outcomes in preterm infants; however, the precise causal relationship remains unclear. In this study, we conducted a two-sample Mendelian randomization (MR) analysis to comprehensively study the relationship between gut microbiota and adverse neurodevelopmental outcomes in preterm infants and identify specific causal bacteria that may be associated with the occurrence and development of adverse neurodevelopmental outcomes in preterm infants. The genome-wide association analysis (GWAS) of the MiBioGen biogroup was used as the exposure data.

Nonlinear state estimation by Extended Parallelotope Set-Membership Filter.

In this paper, we propose a state estimation method called the Extended Parallelotope Set-Membership Filter that provides a higher estimation accuracy than existing methods for discrete-time nonlinear systems. The Extended Parallelotope Set-Membership Filter is motivated by the fact that the iteration operations in existing methods generate much redundancy, and will deteriorate the accuracy of the state estimation. To account for this issue, an innovative parallelotope envelope method is proposed for the purpose of reducing the redundancy arising from the process of the noise envelope.

A novel 2D/3D hierarchical registration framework via principal-directional Fourier transform operator.

An effective registration framework between preoperative 3D computed tomography and intraoperative 2D x-ray images is crucial in image-guided therapy. In this paper, a novel 2D/3D hierarchical registration framework via principal-directional Fourier transform operator (HRF-PDFTO) is proposed. First, a PDFTO was established to obtain the in-plane translation and rotation invariance.

Modulating the antioxidant system by exogenous 2-(3,4-dichlorophenoxy) triethylamine in maize seedlings exposed to polyethylene glycol-simulated drought stress.

Maize (Zea mays L.), an important agricultural crop, suffers from drought stress frequently during its growth period, thus leading to a decline in yield. 2-(3,4-Dichlorophenoxy) triethylamine (DCPTA) regulates many aspects of plant development; however, its effects on crop stress tolerance are poorly understood.

Exogenously applied spermidine alleviates photosynthetic inhibition under drought stress in maize (Zea mays L.) seedlings associated with changes in endogenous polyamines and phytohormones.

Drought stress (DS) is a major environmental factor limiting plant growth and crop productivity worldwide. It has been established that exogenous spermidine (Spd) stimulates plant tolerance to DS. The effects of exogenous Spd on plant growth, photosynthetic performance, and chloroplast ultrastructure as well as changes in endogenous polyamines (PAs) and phytohormones were investigate in DS-resistant (Xianyu 335) and DS-sensitive (Fenghe 1) maize seedlings under well-watered and DS treatments.

Exogenous DCPTA Ameliorates Simulated Drought Conditions by Improving the Growth and Photosynthetic Capacity of Maize Seedlings.

Previous reports have indicated that 2-(3,4-dichlorophenoxy)triethylamine (DCPTA) can promote the growth and photosynthetic capacity of plants. However, only a small number of these studies have focused on crops, and few reports have focused on whether DCPTA affects stress tolerance. In this study, maize (Zea mays L.