Cystatin C and parenchymal thickness/kidney length ratio in Wilms tumor survivors.

Background: This study presents a clinical, biochemical, and sonographic evaluation of single kidneys in Wilms tumor survivors.

Procedure: The function of single kidneys in 26 Wilms tumor survivors (mean age, 11.17 years; mean follow-up, 7.

Does antineoplasm treatment decrease the glomerular filtration rate in children?

Background: The aim of this cross-sectional study was to test the hypothesis that children diagnosed with nephroblastoma experience increased disturbance in renal filtration even after prompt treatment compared to patients treated for other neoplastic childhood diseases.

Procedures: Our study included 127 children and young adults, who were successfully treated for nephroblastoma (n = 34), oncohaematological childhood diseases (n = 58), and other solid tumours (n = 35). In each patient, serum levels of cystatin C, microalbuminuria, and C-reactive protein, and serum and urine levels of creatinine were examined, along with a urine analysis.

Neuroblastoma and opsoclonus-myoclonus-ataxia syndrome--clinical and pathological characteristics.

Introduction: Opsoclonus-myoclonus-ataxia (OMA) syndrome is the most common paraneoplastic neurological syndrome in childhood.

Materials And Methods: We reviewed the literature and reported on clinical and pathological characteristics of four children with OMA and peripheral neuroblastic tumours. In two of the children the onset of neurological symptoms was connected with a vaccination and in one with viral infection.

[Soft tissue sarcomas of the parameningeal region in children--own observations].

Unlabelled: Soft tissue sarcomas (STS) non-Hodgkin's lymphomas and less frequently nasopharyngeal carcinomas are the most common malignancies located in the parameningeal region in children.

Aim: To assess diagnostic and therapeutic problems in children with parameningeal STS treated in the Departments of Paediatric Oncology in Gdansk and Lublin between 1992 and 2006.

Material And Methods: The study includes 17 patients with parameningeal STS; mean age of patients was 5.

[Neurofibromatosis type 1 in children. Experiences of the Gdansk Paediatric Oncohaematology Centre. Preliminary results].

Introduction: Neurofibromatosis type 1 (NF1) is a frequent genetic disorder of autosomal-dominant pattern. The incidence is about 1 per 3000 live births. Patients with NF1 are predisposed to malignancies including soft tissue sarcomas and leukaemias.

[Therapeutic difficulties in soft tissue sarcoma occurring in children with neurofibromatosis type 1 - own observations].

Unlabelled: Neurofibromatosis type I (NF1) is one of the most common genetic disorders in man, predisposing to benign and malignant tumours. The most common malignancies comprise nervous system tumours, less frequently soft tissue sarcomas (STS) and leukaemia - myelodysplasia syndrome. Herein we report five cases of STS diagnosed in children affected with NF1 (3 girls and 2 boys, age: 8 months -17 years).

[Second neoplasms in children with solid tumours in the years 1992-2007. Experiences of Gdańsk medical academy].

Unlabelled: The occurrence of a second tumour is a severe complication of neoplastic disease and its treatment, and it reduces the patient's chances to survive. The aim of the study was to assess the frequency of a second neoplasm and its clinical course in children treated in Gdańsk in the years 1992-2007.

Patients And Methods: There were 420 children and young adults included in the study.

[Analysis of factors influencing treatment results in children with soft tissue head and neck sarcomas - in the material of the Department of Paediatrics, Haematology, Oncology and Endocrinology, Medical University of Gdansk].

Unlabelled: The aim of the study was to analyze the prognostic factors for the outcome in childhood head/neck soft tissue sarcomas (STS) treated in the Department of Paediatrics, Haematology, Oncology and Endocrinology, Medical University of Gdansk between 1992 and 2007.

Material And Methods: Among 23 children with STS in ten it was located in non-parameningeal region, in eight it was in the parameningeal region, and in five in the orbit. Patients were qualified to particular disease stages according to the current diagnostic and therapeutic protocols (Cooperative Weichtel-sarkom Studie-CWS).

Sarcomas in children with neurofibromatosis type 1-poor prognosis despite aggressive combined therapy in four patients treated in a single oncological institution.

Objects: Patients with neurofibromatosis type 1 (NF1) are predisposed to developing soft tissue sarcomas (STS).

Materials And Methods: We report on four cases of STS diagnosed in locally advanced, unresectable stages in children with NF1 (three girls, one boy; age = 8 months-14 years). All patients received protocols for STS: Cooperative Weichteilsarkomstudie 91, 96 and 2002.

[Clinical characteristics and therapy outcome in children with stage IV Hodgkin's lymphoma--the experience of two oncological centres].

Unlabelled: The cure rate in children with Hodgkin's disease (HD), at present time exceeds 90% but the prognosis in stage IV HD is much worse. THE AIM of the study was to analyze the initial symptoms, course and results of oncological therapy in children with stage IV of Hodgkin's disease.

Material And Methods: The analyzed group comprised of 15 patients with IV stage HD (M/F: 11/4, mean age: 12 years), treated from January 1993 to March 2005, in two Polish centres of paediatric oncology in Gdansk and Lublin.

[Complications in children cured from Hodgkin's disease].

Unlabelled: THE AIM of the study was to evaluate the incidence of pulmonary complications in children cured from Hodgkin's disease (HD).

Material And Methods: 42 children with HD were treated in the Department of Paediatrics, Haematology, Oncology and Endocrinology, Medical University of Gdansk, between 1994 and 2004. Stages of HD: II--26 children, III--10, IV--6; general symptoms (group B) were present in 50% of patients.

[Cardio-vascular disorders at the time of diagnosis of malignant solid tumours in children--own experiences].

Unlabelled: Cardio-vascular abnormalities in children with neoplastic disease are observed in some cases even during initial diagnostic examinations. The aim of the study was to evaluate the frequency and characteristics of cardiological and vascular disorders in the initial phase of malignant solid tumors in children.

Material And Methods: The study included 236 paediatric patients diagnosed with malignant solid tumours, treated in the Department of Paediatrics, Haematology, Oncology and Endocrinology, Medical University of Gdańk, between 1992 and 2004.

[Relapses in children with nephroblastoma--a single centre experience].

Unlabelled: The aim of the study was to assess the incidence of relapse and outcome of treatment in children with nephroblastoma relapse.

Material And Methods: In the years 1989-2002 at our centre 67 children were treated for nephroblastoma. Patients were divided into two subgroups.

[Late side-effects of treatment in patients with nephroblastoma].

Unlabelled: The aim of the study was to analyse late side-effects of the antineoplastic treatment in patients with diagnosed nephroblastoma.

Material And Methods: In the years 1986-2002, 80 children were treated in the Gdańsk Centre, for nephroblastoma, 13 of them followed SIOP-6, 25 were treated according to SIOP-9 and the remaining 42, SIOP 93-01 programme.

Results: 70 patients had long-term clinical remission.

[Diagnostic and therapeutic difficulties in soft tissue sarcomas localized in nonparameningeal head and neck region--own experiences].

Introduction: Soft tissue sarcomas (MTM) localized within the nonorbital and non-parameningeal head and neck region in children are associated with favourable prognosis. However in our material we have observed many therapeutic failures in this group of patients. The aim of the study was to analyze the reasons for disappointing results of oncological therapy in children with MTM treated between 1992 and 2004.

[Neurologic symptoms in the course of neuroblastoma in children. Own observations].

Introduction: Neurological origin and multiple localization of neuroblastoma (NB) in children predisposed to the occurrence of neurological deficits. They usually present as symptoms of spinal cord compression, peripheral nerve palsy or central nervous system metastases. The aim of the study was to analyze retrospectively the frequency and characteristics of neurological disorders in patients with NB, treated in the Department of Paediatrics, Oncology, Haematology and Endocrinology, Medical University of Gdansk, Poland, between 1992 and 2004.

[Malignant neoplasms localised in the parameningeal region in children treated at two Polish oncological centres-diagnostic and therapeutic dilemmas].

Unlabelled: Malignant neoplasms localized in the parameningeal region include mainly soft tissue sarcomas (MTM), non-Hodgkin s lymphomas (NHL-B) and, less frequently, nasopharyngeal carcinomas. The aim of the study was to analyze diagnostic and therapeutic problems in children with parameniingeal neoplasms treated in Departments of Paediatric Oncology in Gdansk and Lublin between 1992 and 2004.

Material And Methods: The study includes 32 patients (M/F: 23/9), aged 2 to 17 years, mean 6,3 years.

[Wilms' tumour of unfavorable histology--results of treatment with the SIOP 93-01 protocol at the Gdańsk centre. Preliminary report].

Background: Wilms' tumour is the most common primary renal tumour of childhood. The aim or the study was to evaluate the results of treatment in patients with unfavourable histology Wilms' tumour.

Material And Methods: 44 children were treated for nephroblastoma (Wilms' tumour) according to the SIOP 93-01 protocol in the Department of Paediatrics.

[Stage IV Wilms' tumour -- analysis of treatment results, according to the SIOP 93-01 protocol, at the Medical University of Gdańsk].

The Aim Of The Study: To evaluate the results of treatment in patients with Wilm's' tumor in stage IV at the Gdansk Medical University Centre.

Material And Methods: Between 1993 and 2002, 44 children with nephroblastoma were treated according to SI0P 93-01 protocol, in the Department of Paediatrics, Haematology, Oncology and Endocrinology of the Medical University of Gdansk. Stage IV tumour was confirmed in 6 children: 3 boys and 3 girls.

[Solid tumours of the vertebral column and spinal cord in children. Reasons and consequences of diagnostic delay].

Introduction: Primary or secondary tumours of spinal cord and vertebral column have various histological structure, various degree of malignancy and various growth dynamics. Such localisation of neoplastic disease creates problems, connected with the risk of irreversible damage of neurological functions. It is essential to make a proper diagnosis very early.

[Malignant pelvic neoplasms in children treated in two Polish oncology centres].

Background: Extensive diagnostic and therapeutic dilemmas appear in children With primary malignant neoplasms located in the minor pelvis.

The Aim Of The Study: To evaluate the clinical symptoms, disease course and the results of treatment in patients with malignant pelvic neoplasms.

Material And Methods: The study included 31 children (13 boys and 18 girls; aged 2 months to 16 years; mean age -- 8 years) treated in the Departments of Paediatric Oncology and Haematology in Gdansk and Lublin during the period of 1992-2003.