Publications by authors named "Danuta Paluch"

A knitted implant, unilaterally modified with plasma-assisted chemical-vapor deposition (PACVD), and with a nano-layer of fluorine derivative supplementation, for reducing the risk of complications related to adhesions, and the formation of a thick postoperative scar was prepared. The biological evaluation of designed or modified medical devices is the main aspect of preclinical research. If such studies use a medical device with prolonged contact with connective tissue (more than 30 days), biocompatibility studies require a safety assessment in terms of toxicity in vitro and in vivo, allergenicity, irritation, and cancerogenicity, reproductive and developmental toxicity.

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Purpose: Preventing the formation of blood clots on the surface of biomaterials and investigation of the reasons of their formation are the leading topics of the research and development of biomaterials for implants placed into the bloodstream. Biocompatibility and stability of a material in body fluids and direct effect on blood cell counts components are related both to the structure and physico-chemical state of an implant surface. The aim of this study was to determine haemocompatibility and cytotoxicity of polysulfone-based samples containing nano and micro particles of magnetite (Fe3O4).

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Background: Preventing blood clots formation on the biomaterials surface and finding the causes of their appearance are the leading research subjects while working out biomaterials for grafts into the circulation system. Interaction between the biological environment and the carbon implant is closely connected with the properties of its surface. Implants whith surfaces covered with pyrolytic carbon is characterised by athrombogenity have particular significance in medical applications.

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Background: Biomaterials in the form of thin-film coatings as-deposited on different substrates are nowadays increasingly popular. In particular coatings based on a combination of biocompatible materials (eg. titanium) with metals of high biological activity (eg.

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In this work, we describe a novel technique for producing biocompatible medical products with bioactive properties from the biodegradable polymer dibutyrylchitin (DBC). Materials produced by blowing out polymer solutions have excellent hemostaic properties and are easy to handle during surgery. Biocompatibility studies, encompassing hemostasis and the evaluation of post-implantation reactions, indicate that the biological properties of DBC depend on the molecular mass of the polymer.

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Investigations on implants have proved that not only the kind of material structure, but also the surface character of grafts influences the local reaction of biomaterials. In recent years electrochemical reactions on implants surface leading to the so called zeta potential arouse interests. Applications of these properties has made us carry on experiments on use of biomaterials with active potential on their bio-compatibility.

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Hydroxyapatite (HAp) ceramics based on calcium phosphates, chemical compounds being natural constructive element of bones is now regarded to be one of better implantation materials in osseous surgery and stomatology. HAp is poorly soluble and slowly resorbing in tissues material. Easiness of connecting of hydroxyapatite ceramics with other materials creates possibilities to produce new composites of chemical compounds containing calcium and easier resorbing.

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Natural preparations for replenishing of hyaluronic acid of zoogenous origin used till now, are characterized with quit low biocompatibility and also too short effect of their action. Recently worked out synthetic polyvinylpyrrolidone preparation PVP, contains modification constituting internally netting of microgels to improve polymer bioresistance. The introduce modification can, however influence PVP biocompatibility after deposition into tissues of the living organism.

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Internally netted miscogelatinated preparation on the basis of polyvinylpyrrolidone PVP desioned for viscosuplementation of joint fluid was worked out. Netted structure of microgel grains presents larger resistance to the degrading action of free radicals than analogical linear polymer chains. Application of zoogeous preparations of hyaluronic acid results in short-term effects of their usage in evoking reaction foreign protein.

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Polymethacrylate methylene (PMMA) used as the carrier for antibiotic gentamycin (Septopal) shows today very limited effectiveness. Only 24% of the staphylococcus strains is still susceptible for it. In 1982 this factor was as high as 97%! Because of the growing resistance of different strains of staphylococcus, enterococcus and G(-) bacillus for antibiotics in present use, came into being the necessity for evaluation of the state-of-the-art antibiotic carrier of the new generation, which should be effective to destroy the resistant strains of bacteria.

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The ceramics on the basis of corundum is used for implantation in the form of porous and solid materials. The solid form was used to produce tissue endoprosthesis while porous form is mainly used to fill in the bone defects. The corundum ceramics are also known to be used as coatings for implants in orthopedics and dentistry.

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Investigation of biocompatibility degree of apatite cement as a carrier of antibiotic--vancomycin was the purpose of the experimental study. Investigation of local reactions of muscular tissue was carried out on 18 rats of Wistar type, by implanting samples of apatite cement with vancomycin in the dorsal muscles. Sections of the animals and microscopic investigations were made 7, 14, 30, 90, 180 and 270 days after the implantation.

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The aim of this work was the evaluation of biocompatibility and bioactivity of HAP/TCP as compared to HAP. This evaluation was carried out by the in vitro assessment of the induction of TNF-alpha in the rat blood after the contact with the tested HAP. The anther target was to investigate of local muscle tissue reaction of rats bones reaction of rabbits, after the implantation of tested materials.

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TRICOMED S.A. (Poland) has modified its own knitted polyester vascular prosthesis by change in its physical and chemical characteristics and using hydrophilia.

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The paper presents the studies of the influence polyester knitings with a different degree of surface wettability have on the coagulation system, fibrinolytic system and blood haematological parameters in in vitro studies. The studies of Human whole blood were performed for 5, 15, 30, 60, 90, 180 and 240 min. In view of the obtained results in has been reported that a hydrophobic surface knitting does not cause important quantitative changes in any of the selected parametes of the coagulation system and fibrinolysis system.

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Synopsis of recent research by authors named "Danuta Paluch"

  • - Danuta Paluch's research primarily focuses on the development and evaluation of biocompatible biomaterials, with an emphasis on enhancing the safety and effectiveness of medical implants through innovative modifications and coatings.
  • - Her recent study on a knitted hernia implant involved the use of plasma-assisted chemical-vapor deposition (PACVD) to improve biocompatibility and reduce complications like adhesions and scarring.
  • - Additionally, her investigations into haemocompatibility and cytotoxicity of non-metallic composites reveal significant insights into the prevention of blood clot formation on biomaterials, showcasing the impact of material structure and surface characteristics on their biological interactions.