Interaction between PAMAM-NH₂ G4 dendrimer and 5-fluorouracil in aqueous solution.

The formation equilibrium of poly(amidoamine) dendrimer (PAMAM-NH₂ G4) complex with an oncologic drug such as 5-fluorouracil (5-FU) in water at room temperature was examined. Using the results of the drug solubility in dendrimer solutions and the method of equilibrium dialysis, the maximal number of drug molecules in the dendrimer-drug complex and its equilibrium constant were evaluated. Solubility results show that PAMAM-NH₂ G4 dendrimer can transfer tens 5-fluorouracil molecules in aqueous solution.

In vitro study of AMP-deaminase from fish (Cyprinus carpio) treated with hydrolyzable tannins.

AMP-deaminase (EC 3.5.4.

Na+K+-ATPase activity as a biomarker of toxaphene toxicity in Unio tumidus.

In this study, the effect of toxaphene (camphechlor) on ATPase activity in the microsomal fraction of the Unio tumidus's digestive gland was determined. Toxaphene is a man-made mixture consisting of polychlorinated monoterpens, predominantly bornanes. This compound was primarily used as an insecticide, but in 1982 was officially banned because of its destructive effects on human and animal health.

Effect of red laser light on Na+,K(+)-ATPase activity in human erythrocyte membranes sensitized with Zn-phthalocyanine.

Objective: The influence of laser light (670 nm) on human erythrocyte membrane Na+,K(+)-ATPase activity in the presence and absence of Zn-phthalocyanine (ZnPc) was studied.

Background Data: The response of erythrocyte membranes to low-power laser irradiation has not been fully elucidated. In our study, we focused on the studies on photo-induced changes of Na+,K(+)-ATPase activity.