Publications by authors named "Danuta Dudzinski"
Numerous studies show that 17β-estradiol (E2) protects against Alzheimer's disease (AD) induced neurodegeneration. The E2-synthesizing enzyme aromatase is expressed in healthy hippocampi, but although the hippocampus is severely affected in AD, little is known about the expression of hippocampal aromatase in AD. To better understand the role of hippocampal aromatase in AD, we studied its expression in postmortem material from patients with AD and in a mouse model for AD (5xFAD mice).
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- Aromatase inhibitors like letrozole, which lower estradiol levels, may cause memory issues in women by inducing changes in the brain.
- Letrozole treatment in female mice led to a rapid decline in long-term potentiation (LTP) and cofilin phosphorylation, both important for memory formation and maintenance.
- The study found that the negative effects on brain structure and function were similar in both female and male mice, but the response intensity varied between genders, suggesting significant implications for memory impairments in women using letrozole.
The opposing roles of estradiol on synaptic protein expression in hippocampal cultures.
Psychoneuroendocrinology
December 2009
Estrogen-induced synaptic plasticity was frequently shown by an increase of spines at apical dendrites of CA1 pyramidal neurons after systemic application of estradiol to ovariectomized rats. Surprisingly, exogenous application of estradiol to hippocampal cultures had no effect on spines and on spine synapses, although quantitative immunohistochemistry revealed an upregulation of spinophilin and of synaptophysin, in these cultures. The role of synaptophysin as a presynaptic marker and of spinophilin as a postsynaptic marker, appears questionable from these discrepancies.
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