Publications by authors named "Dante Nicotera"
Article Synopsis
- The study focused on identifying patient characteristics and outcomes related to retropharyngeal abscess (RPA) in children to find predictors of effective surgical treatment.
- Out of 245 pediatric patients studied, 159 had surgery while 86 received only antibiotics; factors like restricted neck motion and CT findings (specifically rim enhancement) were linked to surgical success.
- The research concluded that medical management had a high success rate, while the significant predictor for successful surgical drainage was rim enhancement observed in CT images.
Objectives: Differences in management and outcomes of otolaryngologic diseases may reflect inequities driven by social determinants of health. This study aimed to investigate disparities in presentation and outcomes of retropharyngeal abscess (RPA) among 231 pediatric patients.
Methods: Medical records were searched for pediatric patients with RPA from 2010 to 2021.
Analysis of synonymous mutations established that although the primary amino acid sequence remains unchanged, alterations in transcription and translation can result in significant phenotypic consequences. We report the novel observation that a series of nonsynonymous mutations in an unconserved stretch of amino acids found in the yeast multidrug efflux pump Pdr5 increases expression, thus enhancing multidrug resistance. Cycloheximide chase experiments ruled out the possibility that the increased steady-state level of Pdr5 was caused by increased protein stability.
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