Publications by authors named "Dante Guldbrandsen Andersen"
Article Synopsis
- Researchers have engineered synthetic cells with an artificial signaling pathway that activates gene transcription in response to external triggers, using nature as a guide.
- This involves creating responsive enzymes that can be activated by biochemical stimuli, such as a deactivated creatine kinase for ATP production and a nucleic acid polymerase for RNA synthesis.
- The study highlights the importance of cellular arrangement in biochemistry, demonstrating that separating incompatible components is crucial for effective transcription in these synthetic cells, marking a significant advancement toward creating life-like cell models.
We present three classes of chemical zymogens established around the protein cysteinome. In each case, the cysteine thiol group was converted into a mixed disulfide: with a small molecule, a non-degradable polymer, or with a fast-depolymerizing fuse polymer (Z). The latter was a polydisulfide based on naturally occurring molecule, lipoic acid.
View Article and Find Full Text PDFA vast range of biomedical applications relies on the specificity of interactions between an antigen and its cognate receptor or antibody. This specificity can be highest when said antigen is a non-natural (synthetic) molecule introduced into a biological setting as a bio-orthogonal ligand. This review aims to present the development of this methodology from the early discovery of haptens a century ago to the recent clinical trials.
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