Mid-Term Outcomes of Novel Covered Stent with Biodegradable Membrane in Porcine Coronary Artery Perforation.

Background: Currently, commercially covered stents are the main treatment for coronary artery perforation (CAP), but without satisfied late-term outcomes when compared to drug-eluting stents (DES). This study seeks to report a new covered stent to treat porcine CAP, which is manufactured with DES and a biodegradable membrane fabricated by poly-L-lactic acid (PLLA) polymer.

Methods: Experimental swines experienced CAP in proximal-middle of right coronary artery (RCA) by non-compliant balloon burst, and covered stent was deployed in breach segment.

The relationship between social support and erectile dysfunction in middle-aged and older males.

Background: Erectile dysfunction (ED) is a prevalent condition that affects middle-aged and older men, impacting their sexual health and overall wellbeing. We aimed to investigate the relationship between social support and ED among this specific population.

Methods: Data were collected from the National Health and Nutrition Examination Survey.

Health literacy in patients with gout: A latent profile analysis.

Objectives: Understanding the health literacy status of patients with gout diagnosis is essential for improving the health of this population. Our study aimed to investigate the latent profiles of health literacy in patients with gout and to analyze differences in characteristics across potential profiles.

Methods: This was a cross-sectional study.

The disease recurrence perception scale for patients with inflammatory bowel disease: Instrument development and cross-sectional validation study.

Disease recurrence perception plays a key role in disease management and subsequent disease recurrence prevention. However, there are no specific tools for assessing disease recurrence perception in patients with inflammatory bowel disease (IBD) characterized by alternating remission and recurrence. To develop and validate an instrument for measuring disease recurrence perception of patients with IBD, the study was conducted in two steps: (1) instrument development and (2) psychometric tests.

The efficacy of antiviral treatment in chronic hepatitis B patients with hepatic steatosis.

Background & Aims: With a drastic increase in the number of chronic hepatitis B (CHB) patients with coexisting nonalcoholic fatty liver disease (NAFLD), there is an urgent need to evaluate antiviral treatment effects in this special population.

Methods: CHB patients with hepatic steatosis (CHB + HS) were prospectively recruited with followed-up of 3 years. HS and liver fibrosis were assessed by transient elastography.

A Deep Multi-Task Network to Learn Tumor Pathological Representations for Lymph Node Metastasis Prediction.

Lymph node metastasis is of paramount importance for patient treatment decision-making, prognosis evaluation, and clinical trial enrollment. However, accurate preoperative diagnosis remains challenging. In this study, we proposed a multi-task network to learn the primary tumor pathological features using the pT stage prediction task and leverage these features to facilitate lymph node metastasis prediction.

Zero-shot information extraction from radiological reports using ChatGPT.

Introduction: Electronic health records contain an enormous amount of valuable information recorded in free text. Information extraction is the strategy to transform free text into structured data, but some of its components require annotated data to tune, which has become a bottleneck. Large language models achieve good performances on various downstream NLP tasks without parameter tuning, becoming a possible way to extract information in a zero-shot manner.

Disease severity and antiviral response in patients with chronic hepatitis B with non-obese NAFLD.

Background: The burden of nonalcoholic fatty liver disease (NAFLD) is growing in patients with chronic hepatitis B (CHB). NAFLD is typically associated with obesity, however, it is increasingly being identified in non-obese patients. This study aimed to investigate disease severity and antiviral response in non-obese patients with CHB with NAFLD (CHB + NAFLD).

A Hierarchy-driven Multi-label Network with Label Constraints for Post-operative Complication Prediction of Lung Cancer.

Lung cancer is one of the most dangerous cancers all over the world. Surgical resection remains the only potentially curative option for patients with lung cancer. However, this invasive treatment often causes various complications, which seriously endanger patient health.

Percutaneous Coronary Intervention in Acute Coronary Syndrome with Mild-to-Moderate Thrombocytopenia.

Background:  Baseline thrombocytopenia is commonly observed in patients with acute coronary syndrome (ACS) requiring percutaneous coronary intervention (PCI).

Aim:  The purpose of this analysis was to investigate safety and effectiveness of PCI in ACS patients with baseline mild-to-moderate thrombocytopenia.

Methods:  The data were collected from the Improving Care for Cardiovascular Disease in China-Acute Coronary Syndrome project.

Adropin inhibits the progression of atherosclerosis in ApoE/Enho mice by regulating endothelial-to-mesenchymal transition.

Adropin, a secreted protein, coded by energy homeostasis-associated gene (Enho), is recently reported to modulate atherogenesis, with endothelial-to-mesenchymal transition (EndMT) involved in the early process. We explored whether adropin may alleviate atherosclerosis by regulating EndMT. We found that an intraperitoneal injection of adropin [105 μg/(kg·d) for 13 weeks] inhibited the progression of high-fat diet (HFD)-induced aortic atherosclerosis in apolipoprotein E-deficient mice (ApoE) and those with double gene deletion (ApoE/Enho), as detected by Oil Red O and haematoxylin-eosin staining.

An 18-year evolution of congenital heart disease in China: An echocardiographic database-based study.

Objective: Data on the evolution of congenital heart disease (CHD) in China remain scarce. Based on a Chinese echocardiography database, we analyzed the observed rate (OR) and spectrum changes of CHD over the past 18 years with a focus on the congenital aortic valve malformation (CAVM) and Adult CHD (ACHD).

Methods And Results: The transthoracic echocardiographic data of 682,565 records from 2003 to 2020 were retrospectively reviewed at Fujian Medical University Union Hospital, China.

A Multi-modal Heterogeneous Graph Forest to Predict Lymph Node Metastasis of Non-small Cell Lung Cancer.

Lymph node metastasis (LNM) is critical for treatment decision-making for cancer patients, but it is difficult to diagnose accurately before surgery. Machine learning can learn nontrivial knowledge from multi-modal data to support accurate diagnosis. In this paper, we proposed a Multi-modal Heterogeneous Graph Forest (MHGF) approach to extract the deep representations of LNM from multi-modal data.

Practice of reperfusion in patients with ST-segment elevation myocardial infarction in China: findings from the Improving Care for Cardiovascular Disease in China-Acute Coronary Syndrome project.

Background: Reperfusion therapy is fundamental for ST-segment elevation myocardial infarction (STEMI). However, the details of contemporary practice and factors associated with reperfusion therapy in China are largely unknown. Therefore, this study aimed to explore reperfusion practice and its associated factors among hospitalized patients with STEMI in China.

Inter-hospital transfer in patients with acute myocardial infarction in China: Findings from the improving care for cardiovascular disease in China-acute coronary syndrome project.

Background: Little is known about the current scenario of inter-hospital transfer for patients with acute myocardial infarction (AMI) in China.

Methods: From November 2014 to December 2019, 94,623 AMI patients were enrolled from 241 hospitals in 30 provinces in China. We analyzed the pattern of inter-hospital transfer, and compared in-hospital treatments and outcomes between transferred patients and directly admitted patients.

An ensemble learning with active sampling to predict the prognosis of postoperative non-small cell lung cancer patients.

Background: Lung cancer is the leading cause of cancer death worldwide. Prognostic prediction plays a vital role in the decision-making process for postoperative non-small cell lung cancer (NSCLC) patients. However, the high imbalance ratio of prognostic data limits the development of effective prognostic prediction models.

Pre-hospital delay in patients with acute myocardial infarction in China: findings from the Improving Care for Cardiovascular Disease in China-Acute Coronary Syndrome (CCC-ACS) project.

Objective: To describe the duration of the pre-hospital delay time and identify factors associated with prolonged pre-hospital delay in patients with acute myocardial infarction (AMI) in China.

Methods: Data were collected from November 2014 to December 2019 as part of the Improving Care for Cardiovascular Disease in China-Acute Coronary Syndrome (CCC-ACS) project. A total of 33,386 patients with AMI admitted to the index hospitals were included in this study.

Using Natural Language Processing and Machine Learning to Preoperatively Predict Lymph Node Metastasis for Non-Small Cell Lung Cancer With Electronic Medical Records: Development and Validation Study.

Background: Lymph node metastasis (LNM) is critical for treatment decision making of patients with resectable non-small cell lung cancer, but it is difficult to precisely diagnose preoperatively. Electronic medical records (EMRs) contain a large volume of valuable information about LNM, but some key information is recorded in free text, which hinders its secondary use.

Objective: This study aims to develop LNM prediction models based on EMRs using natural language processing (NLP) and machine learning algorithms.

The Role of Metabolic Factors and Steatosis in Treatment-Naïve Patients with Chronic Hepatitis B and Normal Alanine Aminotransferase.

Introduction: We aimed to elucidate the impact of metabolic syndrome (MS) and nonalcoholic fatty liver disease (NAFLD) on treatment-naïve patients with chronic hepatitis B (CHB) and normal alanine aminotransferase (ALT).

Methods: We analyzed the clinical characteristics of a cross-sectional cohort of treatment-naïve patients with CHB and ALT in the upper limit of normal (ULN) from October 2018 to July 2021. ALT ≤ 0.

End-of-treatment HBcrAg and HBsAb levels identify durable functional cure after Peg-IFN-based therapy in patients with CHB.

Background & Aims: Functional cure can be sustained in a proportion of patients with chronic hepatitis B (CHB) who lose hepatitis B surface antigen (HBsAg) after pegylated interferon alpha (Peg-IFN-ɑ)-based treatment. In this study, we aimed to identify biomarkers associated with a durable functional cure and to dissect potential immunological mechanisms.

Methods: Of 257 nucleos(t)ide analogue-suppressed patients with CHB in the ANCHOR study, 80 patients randomly assigned to 96-week Peg-IFN-α-based therapy with 24-week off-treatment follow-up were included in this parallel study.

Automatic SNOMED CT coding of Chinese clinical terms via attention-based semantic matching.

Background: A considerable amount of meaningful information is routinely recorded in Chinese clinical data in text format, referred to as Chinese clinical terms. The lack of coding is a major difficulty hindering the application of clinical terms. SNOMED CT is a widely used and comprehensive clinical health care terminology collection because of its coverage, granularity, clinical orientation, and logical underpinning.

Outcomes of a Comprehensive Pain Rehabilitation Program for Patients With Fibromyalgia.

Objective: To analyze opioid intake interference with psychological, well-being, and functional outcomes and medication tapering in patients with fibromyalgia admitted to the Mayo Clinic Pain Rehabilitation Program (MCPRP) in Florida.

Patients And Methods: A retrospective study on MCPRP outcomes was conducted. We reviewed the health records of 150 patients with fibromyalgia who participated in the program from May 1, 2014, to May 1, 2015.