Publications by authors named "Danqi Sun"

Chronic rhinosinusitis with nasal polyps (CRSwNPs) is a heterogeneous disease characterized by local inflammation of the upper airway and sinus mucosa. T cell-mediated immune responses play irreplaceable roles in the pathogenesis of nasal polyps. CD161 T cells have been implicated in the pathology of several diseases through cytokine production and cytotoxic activity.

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Purpose: To investigate the value of preoperative diagnosis of colorectal adenocarcinoma (CRAC) pathological T staging based on dual-layer spectral-detector computed tomography (DLCT) extracellular volume fraction (ECV) of CRAC lesions.

Methods: We prospectively collected clinical and DLCT imaging data from 165 patients with CRAC who attended two hospitals from June 2022 to April 2023. The enrolled patients were divided into a training group (n = 110, from Hospital 1) and an external validation group (n = 55, from Hospital 2).

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Background: Preoperative assessment of lymphovascular invasion(LVI) of rectal cancer has very important clinical significance. However, accurate preoperative imaging evaluation of LVI is highly challenging because the resolution of MRI is still limited. Relatively few studies have focused on prediction of LVI of rectal cancer with the tool of radiomics, especially in patients with negative statue of MRI-based extramural vascular invasion (mrEMVI).

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Biological tissues, such as heart valve, tendon, etc., possess excellent mechanical properties, which arises from their inherent anisotropic arrangement of soft and hard phases. Inspired by the anisotropic structures, many methods have been developed to synthesize hydrogels that can achieve mechanical properties comparable to biological tissues.

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The photoelastic effect has many uses in mechanics today, but it is usually disregarded in flexible materials. Using 2-phenoxyethyl acrylate as a monomer and 4-cyano-4'-pentylbiphenyl (5CB) as a solvent, a multiple responsive photoelastic organogel (PO) with strong birefringence but low modulus is created. 5CB is a liquid crystal molecule that does not participate in the polymerization process and is always present as tiny molecules in the polymer.

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Background: The incidence and mortality rate of rectal cancer are still high, the metastasis of rectal cancer are main causes of death. The control of the distant metastasis is one of the main concerns in the treatment of locally advanced rectal cancer, but there are few studies on predicting synchronous distant metastasis (SDM) of rectal cancer.

Method: The data of patients with rectal adenocarcinoma confirmed by endoscopic biopsy or postoperative pathology from September 2015 to May 2020 in hospital A (center 1) and hospital B (center 2) were analyzed retrospectively, including age, sex, carcinoembryonic antigen, carbohydrate antigen 19-9, tumor location, tumor length, image staging and characteristics.

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Article Synopsis
  • The study explored if texture analysis combined with functional MRI could effectively differentiate between early-stage (pT1-2) and advanced-stage (pT3a) rectal cancer in 82 patients before surgery.
  • Results indicated a preoperative MRI accuracy of 74.39% for differentiating the two stages, with significant variations found in certain fMRI parameters like Kep, Ve, and ADC between the groups.
  • A subset of 25 texture features from T2 images showed noteworthy differences, with specific features such as S(0,2)SumOfSqs and WavEnLH_s_2 having strong performance and negative correlations with cancer stage.
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Composite materials have been long developed to improve the mechanical properties such as strength and toughness. Most composites are non-stretchable which hinders the applications in soft robotics. Recent papers have reported a new design of unidirectional soft composite with superior stretchability and toughness.

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Photoelasticity often refers to the birefringence effect of materials induced by elastic deformation. Recently, many experiments on the photoelasticity of soft materials have been reported. However, the experimental results are mainly qualitative observations and lack any theoretical analysis.

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Recent decades have seen intense developments of hydrogel applications for cell cultures, tissue engineering, soft robotics, and ionic devices. Advanced fabrication techniques for hydrogel structures are being developed to meet user-specified requirements. Existing hydrogel 3D printing techniques place substantial constraints on the physical and chemical properties of hydrogel precursors as well as the printed hydrogel structures.

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