Purpose: Interventions to improve the safety and efficiency of manual sterile compounding are needed. This study evaluated the impact of a technology-assisted workflow system (TAWS) on sterile compounding safety (checks, traceability, and error detection), and efficiency (task time).
Methods: Observations were conducted in an oncology pharmacy transitioning from a manual to a TAWS process for sterile compounding.
Introduction: Blood cultures are of limited utility in nonsevere community-acquired pneumonia, though routinely recommended for severe community-acquired pneumonia or health care-associated pneumonia due to perceived greater bacteremia risk, particularly with multidrug-resistant organisms. The utility of this practice is unknown.
Methods: In this observational cohort study, we abstracted data from medical records for consecutive hospitalizations for pneumonia by adults to an academic medical center from 2014-2015.
Germline-expressed endogenous small interfering RNAs (endo-siRNAs) transmit multigenerational epigenetic information to ensure fertility in subsequent generations. In Caenorhabditis elegans, nuclear RNAi ensures robust inheritance of endo-siRNAs and deposition of repressive H3K9me3 marks at target loci. How target silencing is maintained in subsequent generations is poorly understood.
View Article and Find Full Text PDFJ Allergy Clin Immunol Pract
January 2018
Background: Fungal sensitization in patients with asthma has been associated with severe asthma and worse asthma outcomes.
Objective: The purpose of this study was to determine the relationship between fungal and nonfungal sensitization, asthma severity, and clinical outcomes.
Methods: A retrospective review of patients with asthma evaluated in an urban pulmonary subspecialty clinic in the United States was performed.