Publications by authors named "Danny Schreier"
The molecular mechanisms by which lymphatic vessels induce cell contact inhibition are not understood. Here, we identify the cGMP-dependent phosphodiesterase 2A (PDE2A) as a selective regulator of lymphatic but not of blood endothelial contact inhibition. Conditional deletion of Pde2a in mouse embryos reveals severe lymphatic dysplasia, whereas blood vessel architecture remains unaltered.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates the roles of neutrophil extracellular traps (NETs) and coagulation factor XII (FXII) in the severity of COVID-19, revealing increased FXII expression and activity in COVID-19 lung tissues compared to other conditions.
- It finds that the accumulation of NETs in COVID-19 is partly due to impaired clearance by DNases, which can lead to further FXII activation, contributing to inflammation and coagulopathy.
- The findings suggest that targeting the NET/FXII interaction could be a potential therapeutic approach for managing COVID-19 related complications.
Endothelial tip cells are essential for VEGF-induced angiogenesis, but underlying mechanisms are elusive. The Ena/VASP protein family, consisting of EVL, VASP, and Mena, plays a pivotal role in axon guidance. Given that axonal growth cones and endothelial tip cells share many common features, from the morphological to the molecular level, we investigated the role of Ena/VASP proteins in angiogenesis.
View Article and Find Full Text PDF