Publications by authors named "Danny R Ragland"
Severe liver impairment is a well-known hallmark of Ebola virus disease (EVD). However, the role of hepatic involvement in EVD progression is understudied. Medical imaging in established animal models of EVD (e.
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- - Hemorrhagic smallpox, caused by the variola virus, was a nearly 100% fatal disease in humans and often involved serious complications like bacterial infections and bleeding in the heart.
- - Previous studies showed that exposing macaques to the cowpox virus (CPXV) can replicate the effects of human hemorrhagic smallpox for research purposes.
- - This experiment aimed to investigate heart-related issues, finding evidence of acute myocarditis in the CPXV model, which may play an important role in the severity of the disease.
The upsurge of West Nile virus (WNV) human infections in 2012 suggests that the US can expect periodic WNV outbreaks in the future. Availability of safe and effective vaccines against WNV in endemic areas, particularly for aging populations that are at high risk of West Nile neuroinvasive disease (WNND), could be beneficial. WN/DEN4Δ30 is a live, attenuated chimeric vaccine against WNV produced by replacement of the genes encoding the pre-membrane and envelope protein genes of the vaccine virus against dengue virus type 4 (DEN4Δ30) with corresponding sequences derived from a wild type WNV.
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