S-adenosylmethionine (SAMe) as treatment for depression: a systematic review.

Purpose: To assess the evidence evaluating S-adenosylmethionine (SAMe) supplementation as treatment for depression.

Methods: Searches of Medline, Psychinfo, AMED, and Cochrane Controlled Trials Register were conducted from database inception through September 2001. Randomized controlled trials, controlled clinical trials, intervention studies, case-control studies, reviews, and case reports examining the evidence behind S-adenosylmethionine (SAMe) supplementation in depression among humans were selected.