Publications by authors named "Danny Jamoul"
Article Synopsis
- Interactions between neurons, glial cells, and blood vessels are essential for proper retinal blood vessel formation and the development of the blood-retinal barrier (BRB).
- Research using mouse models shows that a lack of glutamate release from neurons delays blood vessel formation and BRB development, while excessive glutamate from activated retinal cells speeds it up.
- The study suggests that neuronal activity affects these processes by influencing Norrin/β-catenin signaling in endothelial cells, and that enhancing this signaling can fix some issues caused by reduced glutamate release.
Interactions among neuronal, glial and vascular components are crucial for retinal angiogenesis and blood-retinal barrier (BRB) maturation. Although synaptic dysfunction precedes vascular abnormalities in many retinal pathologies, how neuronal activity, specifically glutamatergic activity, regulates retinal angiogenesis and BRB maturation remains unclear. Using genetic studies in mice, single-cell RNA-sequencing and functional validation, we show that deep plexus angiogenesis and paracellular BRB maturation are delayed in retinas where neurons fail to release glutamate.
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