Publications by authors named "Dannie Macrin"
Tissue resident adult stem cells are known to participate in tissue regeneration and repair that follows cell turnover, or injury. It has been well established that aging impedes the regeneration capabilities at the cellular level, but it is not clear if the different onset of stem cell aging between individuals can be predicted or prevented at an earlier stage. Here we studied the dental pulp stem cells (DPSCs), a population of adult stem cells that is known to participate in the repair of an injured tooth, and its properties can be affected by aging.
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- Somatic stem cells in adults help maintain organ function but can't regenerate major cell loss, especially in limited-replicating cells like neurons and heart cells.
- The concept of inducing pluripotency in somatic cells emerged to enhance their regenerative abilities, leading to Yamanaka's breakthrough in 2006, which identified 4 crucial genes (OCT-4, SOX-2, KLF-4, c-MYC).
- This study reviews methods for inducing pluripotency, their differentiation applications, and the current status of induced pluripotent stem cells (iPSCs) in clinical trials, aiming to guide researchers in their clinical applications.
In the recent times, stem cell biology has garnered the attention of the scientific fraternity and the general public alike due to the immense therapeutic potential that it holds in the field of regenerative medicine. A breakthrough in this direction came with the isolation of stem cells from human embryo and their differentiation into cell types of all three germ layers. However, the isolation of mesenchymal stem cells from adult tissues proved to be advantageous over embryonic stem cells due to the ethical and immunological naivety.
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