[Literature research and discussion on properties of a new oversea-introduced traditional Chinese medicine Malaysian ginseng(Tongkat Ali)].

Tongkat Ali(Eurycoma longifolia Jack.) is a medicinal plant of Simaroubaceae in Southeast Asia, with centuries of medicinal history. Rich clinical and pharmacological research results have been attained for this plant, which demonstrates diverse and definite effects and high safety, showcasing advantages and broad market prospects to be introduced as a new medicinal plant.

Wide FOV metalens for near-infrared capsule endoscopy: advancing compact medical imaging.

This study presents the design, fabrication, and characterization of a wide field-of-view (FOV) metalens optimized for capsule endoscopy. The metalens achieved a 165° FOV with a high modulation transfer function (MTF) of 300 lines per millimeter (lp/mm) across the entire FOV, operating in the near-infrared (NIR) narrow-bandpass imaging at 940 nm. The performance of the metalens-based system is evaluated using two bandwidths, 12 nm and 32 nm, showing MTF values of 0.

Preparation and Properties of Flexible Phenolic Silicone Hybrid Aerogels for Thermal Insulation.

In order to prepare flexible thermal protection aerogel materials, using dimethyldimethoxysilane (DMDMS) and methyltrimethoxysilane (MTMS) as co-precursors, isocyanate-propyltrimethoxysilane (CFS-006) was added to the co-precursor as a coupling agent, and resorcinol and formaldehyde were added to the sol solution to prepare a phenolic silicone hybrid aerogel (FAS) by the sol-gel method. The prepared FAS aerogel had no phase separation problem, the density was only 0.118 g/cm, the hydrophobic angle reached 155.

NMC-4 Ameliorates Depression-Like Behavior and Neuroinflammation Caused by Chronic Unpredictable Mild Stress.

Depression is a prevalent mental disorder, but the side effects of antidepressants also make depressed patients resistant. Effective and safe antidepressants should be developed from traditional herbs, with the aim of reducing the side effects of antidepressants and improving the efficacy of drugs. In this study, the new macamide compound-4 (NMC-4) was synthesized for the first time, addressing the problem of difficult extraction, isolation, and low content of natural macamide.

Comprehensive lipidomic profiling of human milk from lactating women across varying lactation stages and gestational ages.

An untargeted lipidomic analysis was conducted to investigate the lipid composition of human milk across different lactation stages and gestational ages systematically. A total of 25 lipid subclasses and 934 lipid species as well as 90 free fatty acids were identified. Dynamic changes of the lipids throughout lactation and gestational phases were highlighted.

Impact of Donor Age on Liver Transplant Outcomes in Patients with Acute-on-Chronic Liver Failure: A Cohort Study.

Background/aims: Liver transplantation is the most effective treatment for the sickest patients with acute-on-chronic liver failure (ACLF). However, the influence of donor age on liver transplantation, especially in ACLF patients, is still unclear.

Methods: In this study, we used the data of the Scientific Registry of Transplant Recipients.

The impact of Karnofsky performance status on prognosis of patients with hepatocellular carcinoma in liver transplantation.

Background: Functional performance as measured by the Karnofsky Performance Status (KPS) scale has been linked to the outcomes of liver transplant patients; however, the effect of KPS on the outcomes of the hepatocellular carcinoma (HCC) liver transplant population has not been fully elucidated. We aimed to investigate the association between pre-transplant KPS score and long-term outcomes in HCC patients listed for liver transplantation.

Methods: Adult HCC candidates listed on the Scientific Registry of Transplant Recipients (SRTR) database from January 1, 2011 to December 31, 2017 were grouped into group I (KPS 80-100%, n = 8,379), group II (KPS 50-70%, n = 8,091), and group III (KPS 10-40%, n = 1,256) based on percentage KPS score at listing.

Impact of donor diabetes mellitus status on liver transplant outcomes in patients with acute-on-chronic liver failure.

Background: Liver transplantation (LT) is the most effective way to save patients with acute-on-chronic liver failure (ACLF). However, the impact of donor diabetes mellitus (DM) on LT outcomes in patients with ACLF has not been fully investigated.

Research Design And Methods: We retrospectively analyzed data from the Scientific Registry of Transplant Recipients (SRTR) between January 1, 2008 to December 31, 2017 in this study.

The interaction of T2DM and BMI with NASH in recipients of liver transplants: an SRTR database analysis.

Background: NASH-related liver transplants are increasing because of the obesity epidemic, but the influence of T2DM on various levels of BMI among NASH recipients is unclear.

Research Design And Methods: We analyzed data retrieved from SRTR on 4,515 patients. We divided patients by BMI into five groups: normal weight; overweight; class 1 obesity; class 2 obesity; and class 3 obesity.

Antioxidative and Energy Metabolism-Improving Effects of Maca Polysaccharide on Cyclophosphamide-Induced Hepatotoxicity Mice via Metabolomic Analysis and Keap1-Nrf2 Pathway.

Walp. (Maca), as a natural food supplement, has strong antioxidant and energy metabolism-improving characteristics, and Maca polysaccharide (MP) is its effective component. MP has been shown to mitigate liver damage in previous research, and Cyclophosphamide (CYP)-induced hepatotoxicity is also a major concern in clinical practice.

Evaluation of retinal vessel and perfusion density in migraine patients by optical coherence tomography angiography.

Background: Migraine is a neurovascular disease and has been reported as a risk factor for ocular vascular complications. Our study aimed to compare the retinal vessel density and perfusion density between migraine patients and healthy subjects by optical coherence tomography angiography (OCTA).

Methods: In this prospective study, 23 patients with migraine with aura (MWA) and 31 patients with migraine without aura (MWOA), and 32 age- and gender-matched healthy controls (HC) were enrolled.

miR-296-5p Inhibits the Secretion of Pulmonary Surfactants in Pulmonary Epithelial Cells via the Downregulation of Wnt7b/-Catenin Signaling.

Neonatal respiratory distress syndrome (NRDS) is a common disease that occurs in premature infants. However, the mechanisms underlying the disease remain unclear. microRNAs (miRNAs) have been indicated to play a crucial role in the development of NRDS.

Fructo-oligosaccharides lower serum lipid levels and suppress high-fat/high-sugar diet-induced inflammation by elevating serum and gut levels of short-chain fatty acids.

Objective: This study aimed to investigate the effects of fructo-oligosaccharides (FOS) on serum lipid levels and to determine the mechanisms underlying these effects and the potential role of inflammation.

Methods: Male C57BL/6 mice received a normal diet, a high-fat/high-sugar (HFS) diet, or an HFS diet supplemented with 10% FOS for 10 weeks. intestinal and serum short-chain fatty acid (SCFA) levels were measured by gas chromatography.