Glucose oxidase-amplified CO generation for synergistic anticancer therapy via manganese carbonyl-caged MOFs.

Carbon monoxide (CO) as one of the therapeutic gaseous molecules has been widely applied for treating various diseases, especially in cancer therapy. However, the in situ-triggered and efficient transport of CO to tumors are the primary obstacles that limit its clinical applicability. To address this obstacle, herein, a HO-triggered CO gas releasing nanoplatform has been designed by embedding manganese carbonyl (MnCO) into Zr (IV)-based metal-organic frameworks (MOFs).

Glucose Oxidase Integrated Porphyrinic Covalent Organic Polymers for Combined Photodynamic/Chemodynamic/Starvation Therapy in Cancer Treatment.

The anticancer effect of photodynamic therapy (PDT) is usually impeded by the hypoxia microenvironment in solid tumors; thus, it requires integration with other treatment tactics to achieve an optimal anticancer efficacy. Porphyrin-containing nanotherapeutic agents are broadly used for PDT in tumor treatment. However, chemodynamic therapy (CDT) of porphyrin-based namomaterials has been rarely reported.

Rim-differentiated pillar[5]arene based nonporous adaptive crystals.

The first rim-differentiated pillar[5]arene based nonporous adaptive crystals (NACs) were developed and used to separate dichloromethane from a halomethane mixture with 99.1% purity.

GOx-assisted synthesis of pillar[5]arene based supramolecular polymeric nanoparticles for targeted/synergistic chemo-chemodynamic cancer therapy.

Background: Cancer is the most serious world's health problems on the global level and various strategies have been developed for cancer therapy. Pillar[5]arene-based supramolecular therapeutic nano-platform (SP/GOx NPs) was constructed successfully via orthogonal dynamic covalent bonds and intermolecular H-bonds with the assistance of glucose oxidase (GOx) and exhibited efficient targeted/synergistic chemo-chemodynamic cancer therapy.

Methods: The morphology of SP/GOx NPs was characterized by DLS, TEM, SEM and EDS mapping.