Publications by authors named "Danlin Zhou"
Article Synopsis
- NIRF is a new E3 ubiquitin ligase that interacts with HBc, leading to its degradation, which impacts HBV replication.
- The study demonstrates that NIRF significantly inhibits HBV DNA replication and the secretion of viral proteins (HBsAg and HBeAg) in both human liver cells and mouse models.
- NIRF also decreases the acetylation of H3 histones associated with HBV cccDNA, indicating a role in the regulation of HBV's replication cycle.
