Publications by authors named "Danli Ran"

Thermogenic brown adipose tissue (BAT) has emerged as an attractive target for combating obesity. However, pharmacological activation of energy expenditure by BAT and/or induction of browning of white adipose tissue (WAT) has been hampered by cardiovascular side effects. To address these concerns, we developed polylactide-co-glycolide acid (PLGA) microspheres loaded with mirabegron (MIR), a selective beta-3 adrenergic receptor (ADRB3) agonist, to achieve sustained local induction and activation of thermogenic adipocytes.

View Article and Find Full Text PDF

Datasets consist of measurement data and metadata. Metadata provides context, essential for understanding and (re-)using data. Various metadata standards exist for different methods, systems and contexts.

View Article and Find Full Text PDF

Chikungunya virus (CHIKV) infection, a febrile illness caused by a mosquito-transmitted alphavirus, has afflicted millions of people worldwide. There is currently no approved effective antiviral treatment for CHIKV infection. In this study, we report a new class of small-molecule CHIKV inhibitors, the oxindole-labdanes, that potently block the replication of CHIKV with good selectivity.

View Article and Find Full Text PDF

Synopsis of recent research by authors named "Danli Ran"

  • - Danli Ran's research spans the fields of pharmacology and data science, focusing on innovative therapeutic strategies and data management frameworks in biomedical research.
  • - One notable study investigates the use of mirabegron-loaded microspheres to enhance browning of adipose tissue as a potential obesity treatment, mitigating cardiovascular side effects commonly associated with traditional pharmacological approaches.
  • - Another area of his work involves the development of labdane-oxindole hybrids as effective small-molecule inhibitors for chikungunya virus, addressing the urgent need for antiviral treatments for this widespread infection.

A PHP Error was encountered

Severity: Warning

Message: fopen(/var/lib/php/sessions/ci_sessiono5srvsu6lku2tjiusk7tdkjc4u1ko79k): Failed to open stream: No space left on device

Filename: drivers/Session_files_driver.php

Line Number: 177

Backtrace:

File: /var/www/html/index.php
Line: 316
Function: require_once

A PHP Error was encountered

Severity: Warning

Message: session_start(): Failed to read session data: user (path: /var/lib/php/sessions)

Filename: Session/Session.php

Line Number: 137

Backtrace:

File: /var/www/html/index.php
Line: 316
Function: require_once