Manifestations of hereditary colorectal cancer.

Seven families with hereditary colorectal cancer syndromes are presented. Four are of the nonpolyposis type, two with polyposis, and one with a mixed pattern. We have observed an early onset of hereditary colorectal cancer, the nonpolyposis type of which manifests itself mostly in the proximal colon, whereas the syndrome with polyposis manifests itself in the distal colon.

Periampullary, colorectal and gastric cancer in two siblings.

We describe a sibship affected by subsequent periampullary, colorectal and gastric carcinoma. Three of 4 siblings (2 males, 1 female) developed a periampullary carcinoma at the age of 20, and the 2 brothers subsequently had colorectal and gastric carcinoma. One of them also had familial adenomatous polyposis.