Publications by authors named "Danko Skare"
Radioprotective and antitumor activity evaluation of newly synthesized adamantyl tenocyclidines.
Cancer Biother Radiopharm
October 2003
Article Synopsis
- Several new adamantyl derivatives of thienyl phencyclidine (TCP) were synthesized and tested for biological activity, focusing on their effects on human tumor cells and nonmalignant mouse fibroblasts.
- These derivatives, particularly TAMORPH, showed reduced toxicity and improved radioprotective properties compared to TCP, promoting greater apoptotic death in cancer cells.
- In vivo studies on C3Hf mice indicated that these derivatives provided enhanced radioprotection while being less toxic than the original TCP compound.
Article Synopsis
- The study assessed the effectiveness of thienyl phencyclidine (TCP) and its new derivatives against organophosphate and carbamate poisoning in mice.
- Both TCP and its derivatives showed low toxicity levels and provided protective effects when used with atropine, particularly against carbamate poisons like propoxur and aldicarb.
- However, their efficacy was reduced for organophosphate poisons; the best results were achieved using a combination of HI-6 (an antidote) with atropine and the test compounds against soman poisoning.