Publications by authors named "Danjie Yao"
Article Synopsis
- Circ_0008345, a type of circular RNA found to be upregulated in colorectal cancer (CRC), plays a significant role in promoting cancer progression by interacting with microRNA (miR)-182-5p and the oncogene CYP1A2.
- The study utilized various assays to demonstrate that when circ_0008345 is knocked down, it inhibits CRC cell growth and movement, as well as tumor formation in mice, indicating its critical role in cancer development.
- The expression of circ_0008345 is regulated by the m6A methylation process mediated by METTL3, underscoring a complex interplay between these molecules that contributes to the aggressive nature of CRC.
Circular RNAs (circRNAs) are a class of stable non-coding RNAs that have emerged as key regulators in human diseases including cancer. This study investigates the role of circRNA_0102913 (circ_0102913) in malignant behavior of colorectal cancer (CRC) cells and the underpinning mechanisms. By analyzing CRC-related GSE197991, GSE159669, and GSE223001 datasets, we obtained circ_0102913 as an aberrantly upregulated circRNA in CRC.
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