Effects of Long-Term Caffeine Consumption on the Adenosine A Receptor in the Rat Brain: an In Vivo PET Study with [F]CPFPX.

Purpose: Caffeine, a nonselective antagonist of adenosine receptors, is the most popular psychostimulant worldwide. Recently, a protective role of moderate chronic caffeine consumption against neurodegenerative diseases such as Alzheimer's and Parkinson's disease has been discussed. Thus, aim of the present study was an in vivo investigation of effects of long-term caffeine consumption on the adenosine A receptor (AAR) in the rat brain.