Improving Fertility in Non-obstructive Azoospermia: Results from an Autologous Bone Mar-row-Derived Mesenchymal Stromal/Stem Cell Phase I Clinical Trial.

Background: In this phase I clinical trial, our primary objective was to develop an innovative therapeutic approach utilizing autologous bone marrow-derived mesenchymal stromal/stem cells (BM-MSCs) for the treatment of nonobstructive azoospermia (NOA). Additionally, we aimed to assess the feasibility and safety of this approach.

Materials And Methods: We recruited 80 participants in this non-randomized, open-label clinical trial, including patients undergoing NOA treatment using autologous BM-MSCs (n=40) and those receiving hormone therapy as a control group (n=40).

Investigation of Hydrophysical Properties and Corrosion Resistance of Modified Self-Compacting Concretes.

Improvement of hydrophysical properties and corrosion resistance of self-compacting concrete to the effects of alternate freezing-thawing and aggressive soils of Southern and Central Kazakhstan is of interest to a wide range of researchers from the side of practical application of the obtained results in construction practice. It is proposed to form a spatially reinforced fine crystalline structure of a cement matrix with the maximum dense packing by using a complex modifier (hyperplasticizer + polymer + microsilica + fibro fibers) in the composition of self-compacting concretes (SCCs). The introduction of the calculated amount of the above additives increases the operational reliability of the current SCC compositions, increasing the water resistance to W16, frost resistance to F = 500, increasing the compressive strength by 20%, and reducing the mass loss of samples during corrosion leaching to 50%.

Frost-Resistant Rapid Hardening Concretes.

This article presents the results of research conducted to determine the possibility of accelerating strength gain and enhancing the operational reliability of concrete. The study tested the effects of modern modifiers on concrete in order to select the composition of rapid hardening concrete (RHC) with better frost resistance characteristics. A basic composition of RHC grade C 25/30 was developed using traditional concrete calculations.

The Effect of Low-Modulus Plastic Fiber on the Physical and Technical Characteristics of Modified Heavy Concretes Based on Polycarboxylates and Microsilica.

Manufacturers of building materials strive to optimize the three basic concrete properties-strength, durability, and shrinkage deformation, of which the focus is generally on the durability in the structure when designing and monitoring the poured concrete. Studying concretes' structural performance and the change in their characteristics over time enables the solution of many important issues associated with the design of reliable, durable, and cost-effective buildings and structures. This article presents studies aimed at improving the physical, technical, and operational characteristics of cement concrete and reducing cement consumption in heavy concretes through the use of complex modifiers and volumetric fiber reinforcement.

Surgical Reconstruction of Penile Curvature due to Peyronie's Disease by Plaque Incision and Buccal Mucosa Graft.

Background/aim: We aimed to evaluate the effectiveness and safety of penile plaque incision and buccal mucosa grafting in patients with stable-phase Peyronie's disease (PD).

Methods: This was a prospective evaluation of patients with stable-phase PD who were treated by plaque incision and buccal mucosa grafting. Preoperative evaluation included International Index of Erectile Function Questionnaire (IIEF-5), measurement of erect penile length, and penile Doppler ultrasound during prostaglandin-induced erection.